Journal of Clinical Immunology

, Volume 26, Issue 1, pp 40–54

HIV-1-Specific CD4+ T Cell Responses in Chronically HIV-1 Infected Blippers on Antiretroviral Therapy in Relation to Viral Replication Following Treatment Interruption

Authors

  • Emmanouil Papasavvas
    • The Wistar Institute
  • Jay R. Kostman
    • Philadelphia Field Initiating Group for HIV-1 Trials
    • Division of Infectious DiseasesUniversity of Pennsylvania
  • Brian Thiel
    • The Wistar Institute
  • Maxwell Pistilli
    • The Wistar Institute
  • Agnieszka Mackiewicz
    • The Wistar Institute
  • Andrea Foulkes
    • Center for Clinical Epidemiology and BiostatisticsUniversity of Pennsylvania
  • Robert Gross
    • Division of Infectious DiseasesUniversity of Pennsylvania
    • Center for Clinical Epidemiology and BiostatisticsUniversity of Pennsylvania
  • Kimberly A. Jordan
    • The Gladstone Institute of Virology and ImmunologyUniversity of California
  • Douglas F. Nixon
    • The Gladstone Institute of Virology and ImmunologyUniversity of California
    • Department of MedicineUniversity of California
  • Robert Grant
    • The Gladstone Institute of Virology and ImmunologyUniversity of California
    • Department of MedicineUniversity of California
  • Jean-francois Poulin
    • The Gladstone Institute of Virology and ImmunologyUniversity of California
  • Joseph M. Mccune
    • The Gladstone Institute of Virology and ImmunologyUniversity of California
    • Department of MedicineUniversity of California
  • Karam Mounzer
    • Philadelphia Field Initiating Group for HIV-1 Trials
    • Philadelphia Field Initiating Group for HIV-1 Trials
    • the Wistar Institute
Article

DOI: 10.1007/s10875-006-7518-8

Cite this article as:
Papasavvas, E., Kostman, J.R., Thiel, B. et al. J Clin Immunol (2006) 26: 40. doi:10.1007/s10875-006-7518-8

Abstract

The impact of transient viral load blips on anti-HIV-1 immune responses and on HIV-1 rebound following treatment interruption (TI) is not known. Clinical and immunological parameters were measured during 40 weeks of antiretroviral therapy (ART) and following TI in an observational cohort of 16 chronically HIV-1-infected subjects with or without observed viral load blips during ART. During therapy, blips in seven subjects were associated with higher anti-HIV-1 (p24) CD4+ T cell lymphoproliferative responses (p = 0.04), without a significant difference in T cell activation or total anti-HIV-1 CD8+ T cell interferon-γ (IFN-γ) responses when compared to nine matched non-blippers. Therapy interruption resulted in a significantly higher viral rebound in blippers by 8 week despite retention of higher lymphoproliferative p24 responses (p = 0.01) and a rise in CD3+ T cell activation (p = 0.04) and anti-HIV-1 CD8+ T cell responses in blippers by week 4 when compared to non-blippers. Past week 4 of interruption, therapy re-initiation criteria were also met by a higher frequency in blippers by week 14 (p < 0.04) with no difference between groups by week 24. These data support that blippers have higher anti-HIV lymphoproliferative responses while on ART but experience equal to higher viral rebound as compared to matched non-blippers upon TI.

Keywords

BlipsHIVtreatment interruptionCD4+ T cell responses
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Copyright information

© Springer Science + Business Media, Inc. 2006