Article

Journal of Clinical Immunology

, Volume 25, Issue 4, pp 385-391

Primary Immune Deficiencies Presenting in Adults: Seven Years of Experience from Iran

  • Davood MansouriAffiliated withNational Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical SciencesDirector Division of Infectious Diseases & Clinical Immunology, National Research Institute of Tuberculosis & Lung Diseases, Shahid Beheshti University of Medical Sciences Email author 
  • , Parisa AdimiAffiliated withNational Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences
  • , Mehdi MirsaediAffiliated withNational Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences
  • , Nahal MansouriAffiliated withNational Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences
  • , Payam TabarsiAffiliated withNational Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences
  • , Majid AmiriAffiliated withNational Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences
  • , Hamid R. JamaatiAffiliated withNational Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences
  • , Masoud MotavasseliAffiliated withNational Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences
  • , Noushin BaghaiiAffiliated withNational Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences
    • , Ali CheraghvandiAffiliated withNational Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences
    • , Reza RouhiAffiliated withNational Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences
    • , Navid A. RoozbahanyAffiliated withNational Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences
    • , Soheila ZahirifardAffiliated withNational Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences
    • , Forouzan MohammadiAffiliated withNational Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences
    • , Mohammad R. MasjediAffiliated withNational Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences
    • , Ali A. VelayatiAffiliated withNational Research Institute for Tuberculosis and Lung Diseases, Masih Daneshvary Hospital, Shahid Beheshti University of Medical Sciences
    • , Jean L. CasanovaAffiliated withLaboratory of Human Genetics of Infectious Diseases, University of Paris
    • , David P. SpeertAffiliated withBC Children’s Hospital and BC Research Institute for Children’s and Women’s Health
    • , R. Kevin ElwoodAffiliated withFaculty of Medicine, University of British Columbia
    • , Robert SchellenbergAffiliated withPulmonary Research Laboratory, University of British Columbia
    • , Stuart E. TurveyAffiliated withBC Children’s Hospital and BC Research Institute for Children’s and Women’s Health

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Abstract

Primary immunodeficiencies (PIDs) are not solely diseases of childhood. We describe the clinical presentation and outcome for 55 adult patients with previously unrecognized PIDs. This series provides unique data regarding PIDs presenting in adulthood, and serves as a timely reminder that physicians must consider the diagnosis of PIDs in their adult patients. Using the experience gained from these patients, we outline key “warning signs” suggestive of an underlying PID. Only through increased physician awareness will patients with PIDs receive timely diagnosis and optimal management.

Key Words

Primary immunodeficiency adults Iran diagnostic delay