Synthesis, Crystal Structure and Antibacterial Activity of N,N′-Bis(4-methoxy-benzylidene)-1,4-bis(3-aminopropyl)piperazine
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- Xu, RB., Zhang, N., Zhou, HY. et al. J Chem Crystallogr (2012) 42: 928. doi:10.1007/s10870-012-0338-1
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A new Schiff base, N,N′-bis(4-methoxy-benzylidene)-1,4-bis(3-aminopropyl)piperazine (BMBA), has been synthesized by the reaction of 1,4-bis(3-aminopropyl)piperazine and 4-methoxy-benzaldehyde in methanol solution. The title compound was characterized by elemental analysis, IR spectrum, 1H NMR, 13C NMR and X-ray single crystal diffraction analyses. The compound crystallizes in the monoclinic system with space group C2/c and a = 24.071(5), b = 9.4035(19), c = 11.263(2) Å, β = 96.787(2)°, V = 2531.6(9) Å3, Dc = 1.193 g/cm3, Mr = 454.60, Z = 4, F (000) = 984, μ = 0.079 mm−1, R1 = 0.0693, and ωR2 = 0.2269. In the crystal structure, molecules of BMBA and water of crystallization are linked through intermolecular O2W–H2′···N2 hydrogen bond, forming a 1D hydrogen bonding network that generates planar “ribbons” running parallel to the c-axis. Furthermore, the antibacterial activity of title compound was investigated preliminary by agar diffusion method, and it exhibited certain inhibited effect against Escherichia coli, Staphylococcus aureus and Bacillus subtilis.