Journal of Bioenergetics and Biomembranes

, Volume 39, Issue 3, pp 243–246

A pivotal role for p53: balancing aerobic respiration and glycolysis

  • Wenzhe Ma
  • Ho Joong Sung
  • Joon Y. Park
  • Satoaki Matoba
  • Paul M. Hwang
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DOI: 10.1007/s10863-007-9083-0

Cite this article as:
Ma, W., Sung, H.J., Park, J.Y. et al. J Bioenerg Biomembr (2007) 39: 243. doi:10.1007/s10863-007-9083-0
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Abstract

The genetic basis of increased glycolytic activity observed in cancer cells is likely to be the result of complex interactions of multiple regulatory pathways. Here we review the recent evidence of a simple genetic mechanism by which tumor suppressor p53 regulates mitochondrial respiration with secondary changes in glycolysis that are reminiscent of the Warburg effect. The biological significance of this regulation of the two major pathways of energy generation by p53 remains to be seen.

Keywords

Synthesis of cytochrome c oxidase 2Cytochrome c oxidaseTumor protein p53

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Wenzhe Ma
    • 1
  • Ho Joong Sung
    • 1
  • Joon Y. Park
    • 1
  • Satoaki Matoba
    • 2
  • Paul M. Hwang
    • 1
  1. 1.Cardiology Branch, National Heart, Lung, and Blood InstituteNational Institutes of HealthBethesdaUSA
  2. 2.Department of Cardiovascular MedicineKyoto Prefectural University of MedicineKyotoJapan