Mini Review

Journal of Bioenergetics and Biomembranes

, Volume 39, Issue 3, pp 243-246

First online:

A pivotal role for p53: balancing aerobic respiration and glycolysis

  • Wenzhe MaAffiliated withCardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
  • , Ho Joong SungAffiliated withCardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
  • , Joon Y. ParkAffiliated withCardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health
  • , Satoaki MatobaAffiliated withDepartment of Cardiovascular Medicine, Kyoto Prefectural University of Medicine
  • , Paul M. HwangAffiliated withCardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health Email author 

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Abstract

The genetic basis of increased glycolytic activity observed in cancer cells is likely to be the result of complex interactions of multiple regulatory pathways. Here we review the recent evidence of a simple genetic mechanism by which tumor suppressor p53 regulates mitochondrial respiration with secondary changes in glycolysis that are reminiscent of the Warburg effect. The biological significance of this regulation of the two major pathways of energy generation by p53 remains to be seen.

Keywords

Synthesis of cytochrome c oxidase 2 Cytochrome c oxidase Tumor protein p53