Journal of Bioenergetics and Biomembranes

, Volume 37, Issue 6, pp 509–515

The Intracellular Antigen Transport Machinery TAP in Adaptive Immunity and Virus Escape Mechanisms

Authors

  • Christian Schölz
    • Institute of Biochemistry, BiocenterJohann Wolfgang Goethe-University Frankfurt
    • Institute of Biochemistry, BiocenterJohann Wolfgang Goethe-University Frankfurt
Article

DOI: 10.1007/s10863-005-9500-1

Cite this article as:
Schölz, C. & Tampé, R. J Bioenerg Biomembr (2005) 37: 509. doi:10.1007/s10863-005-9500-1

 

The transporter associated with antigen processing (TAP) is a crucial element of the adaptive immune system, which translocates proteasomal degradation products into the endoplasmic reticulum, for transfer of these peptides on major histocompatibility complex (MHC) I molecules within a macromolecular peptide-loading complex. After loading and intracellular transport to the cell surface, these peptide/MHC complexes are monitored by cytotoxic T-lymphocytes. This review summarizes the structural organization and function of the ABC transporter TAP. Furthermore, we discuss human diseases and viral evasion strategies associated with TAP function.

Key Words

ABC transporterantigen presentationherpes virusimmune evasionmembrane proteinstransport ATPasestransporter associated with antigen processingvirus persistence

Abbreviations

ABC

ATP-binding cassette

MHC

major histocompatibility complex

NBD

nucleotide-binding domain

TAP

transporter associated with antigen processing

TMD

transmembrane domain

Copyright information

© Springer Science + Business Media, Inc. 2005