Article

Journal of Bioenergetics and Biomembranes

, Volume 37, Issue 6, pp 509-515

The Intracellular Antigen Transport Machinery TAP in Adaptive Immunity and Virus Escape Mechanisms

  • Christian SchölzAffiliated withInstitute of Biochemistry, Biocenter, Johann Wolfgang Goethe-University Frankfurt
  • , Robert TampéAffiliated withInstitute of Biochemistry, Biocenter, Johann Wolfgang Goethe-University Frankfurt Email author 

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The transporter associated with antigen processing (TAP) is a crucial element of the adaptive immune system, which translocates proteasomal degradation products into the endoplasmic reticulum, for transfer of these peptides on major histocompatibility complex (MHC) I molecules within a macromolecular peptide-loading complex. After loading and intracellular transport to the cell surface, these peptide/MHC complexes are monitored by cytotoxic T-lymphocytes. This review summarizes the structural organization and function of the ABC transporter TAP. Furthermore, we discuss human diseases and viral evasion strategies associated with TAP function.

Key Words

ABC transporter antigen presentation herpes virus immune evasion membrane proteins transport ATPases transporter associated with antigen processing virus persistence