Journal of Bioenergetics and Biomembranes

, Volume 37, Issue 6, pp 509–515

The Intracellular Antigen Transport Machinery TAP in Adaptive Immunity and Virus Escape Mechanisms


DOI: 10.1007/s10863-005-9500-1

Cite this article as:
Schölz, C. & Tampé, R. J Bioenerg Biomembr (2005) 37: 509. doi:10.1007/s10863-005-9500-1


The transporter associated with antigen processing (TAP) is a crucial element of the adaptive immune system, which translocates proteasomal degradation products into the endoplasmic reticulum, for transfer of these peptides on major histocompatibility complex (MHC) I molecules within a macromolecular peptide-loading complex. After loading and intracellular transport to the cell surface, these peptide/MHC complexes are monitored by cytotoxic T-lymphocytes. This review summarizes the structural organization and function of the ABC transporter TAP. Furthermore, we discuss human diseases and viral evasion strategies associated with TAP function.

Key Words

ABC transporterantigen presentationherpes virusimmune evasionmembrane proteinstransport ATPasestransporter associated with antigen processingvirus persistence



ATP-binding cassette


major histocompatibility complex


nucleotide-binding domain


transporter associated with antigen processing


transmembrane domain

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  1. 1.Institute of Biochemistry, BiocenterJohann Wolfgang Goethe-University FrankfurtFrankfurt a.M.Germany