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Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties

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Abstract

Novel copolymers of vinyl acetate and dialkylfumarates, poly(VA-co-DRF) with R = isopropyl (DIPF) or octan-2-yl (DOF), were synthesized by radical copolymerization under microwave conditions. The products were characterized by 1H NMR and FTIR spectroscopies, size exclusion chromatography and differential scanning calorimetry. Based on these copolymers three membranes supported on polyvinyl alcohol were prepared and their morphology, swelling and mechanical properties were studied. The swelling kinetic was analyzed and interpreted in light of the Fick transport model, showing that the water transport occurs through a non-Fickian diffusion mechanism. The results show that the membrane prepared of poly(VA-co-DOF) exhibited excellent properties as potential platform for transdermal delivery system: they exhibited good tensile strength, moderated swelling and form thin and transparent films.

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Acknowledgments

This work was supported by Universidad Nacional de La Plata (Project 11/X515). The authors are grateful to Fernando Amarilla for measuring the mechanical properties.

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Authors and Affiliations

  1. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), CONICET, CCT, La Plata, Argentina

    Magalí Pasqualone, Tamara G. Oberti & M. Susana Cortizo

  2. Laboratorio de Farmacotécnia, Departamento Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900, La Plata, Argentina

    Héctor A. Andreetta

Authors
  1. Magalí Pasqualone
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  2. Tamara G. Oberti
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  3. Héctor A. Andreetta
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  4. M. Susana Cortizo
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Correspondence to M. Susana Cortizo.

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Pasqualone, M., Oberti, T.G., Andreetta, H.A. et al. Fumarate copolymers-based membranes overlooking future transdermal delivery devices: synthesis and properties. J Mater Sci: Mater Med 24, 1683–1692 (2013). https://doi.org/10.1007/s10856-013-4925-2

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  • DOI: https://doi.org/10.1007/s10856-013-4925-2

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