Article

Journal of Materials Science: Materials in Medicine

, Volume 24, Issue 2, pp 395-403

Osteoblast, fibroblast and in vivo biological response to poly(vinylidene fluoride) based composite materials

  • R. CostaAffiliated withDepartment of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto
  • , C. RibeiroAffiliated withCentro/Departamento de Física, Universidade do Minho, Campus de GualtarINL—International Iberian Nanotechnology Laboratory
  • , A. C. LopesAffiliated withCentro/Departamento de Física, Universidade do Minho, Campus de Gualtar
  • , P. MartinsAffiliated withCentro/Departamento de Física, Universidade do Minho, Campus de GualtarINL—International Iberian Nanotechnology Laboratory
  • , V. SencadasAffiliated withCentro/Departamento de Física, Universidade do Minho, Campus de GualtarEscola Superior de Tecnologia, Instituto Politécnico do Cávado e do Ave, Campus do IPCAINL—International Iberian Nanotechnology Laboratory
  • , R. SoaresAffiliated withDepartment of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto
  • , S. Lanceros-MendezAffiliated withCentro/Departamento de Física, Universidade do Minho, Campus de GualtarINL—International Iberian Nanotechnology Laboratory Email author 

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Abstract

Electroactive materials can be taken to advantage for the development of sensors and actuators as well as for novel tissue engineering strategies. Composites based on poly(vinylidene fluoride), PVDF, have been evaluated with respect to their biological response. Cell viability and proliferation were performed in vitro both with Mesenchymal Stem Cells differentiated to osteoblasts and Human Fibroblast Foreskin 1. In vivo tests were also performed using 6-week-old C57Bl/6 mice. It was concluded that zeolite and clay composites are biocompatible materials promoting cell response and not showing in vivo pro-inflammatory effects which renders both of them attractive for biological applications and tissue engineering, opening interesting perspectives to development of scaffolds from these composites. Ferrite and silver nanoparticle composites decrease osteoblast cell viability and carbon nanotubes decrease fibroblast viability. Further, carbon nanotube composites result in a significant increase in local vascularization accompanied an increase of inflammatory markers after implantation.