In vitro studies of calcium phosphate silicate bone cements
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A novel calcium phosphate silicate bone cement (CPSC) was synthesized in a process, in which nanocomposite forms in situ between calcium silicate hydrate (C–S–H) gel and hydroxyapatite (HAP). The cement powder consists of tricalcium silicate (C3S) and calcium phosphate monobasic (CPM). During cement setting, C3S hydrates to produce C–S–H and calcium hydroxide (CH); CPM reacts with the CH to precipitate HAP in situ within C–S–H. This process, largely removing CH from the set cement, enhances its biocompatibility and bioactivity. The testing results of cell culture confirmed that the biocompatibility of CPSC was improved as compared to pure C3S. The results of XRD and SEM characterizations showed that CPSC paste induced formation of HAP layer after immersion in simulated body fluid for 7 days, suggesting that CPSC was bioactive in vitro. CPSC cement, which has good biocompatibility and low/no cytotoxicity, could be a promising candidate as biomedical cement.
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- In vitro studies of calcium phosphate silicate bone cements
Journal of Materials Science: Materials in Medicine
Volume 24, Issue 2 , pp 355-364
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- 1. Department of Materials Engineering, University of British Columbia, 309-6350 Stores Road, Vancouver, BC, V6T 1Z4, Canada
- 2. Department of Oral Biological & Medical Sciences, Faculty of Dentistry, University of British Columbia, 2199 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada
- 3. Department of Endodontics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China