Journal of Materials Science: Materials in Medicine

, Volume 23, Issue 3, pp 835–851

Osteoblast-like cell response to calcium phosphate coating chemistry and morphology on etched silicon surfaces

Authors

    • Northern Ireland Bioengineering CentreUniversity of Ulster
  • Chris J. Rea
    • Northern Ireland Bioengineering CentreUniversity of Ulster
  • Fergal G. Horgan
    • Northern Ireland Bioengineering CentreUniversity of Ulster
  • Marie Turkington
    • Northern Ireland Bioengineering CentreUniversity of Ulster
  • Adrian R. Boyd
    • Northern Ireland Bioengineering CentreUniversity of Ulster
  • Brian J. Meenan
    • Northern Ireland Bioengineering CentreUniversity of Ulster
Article

DOI: 10.1007/s10856-011-4542-x

Cite this article as:
Burke, G.A., Rea, C.J., Horgan, F.G. et al. J Mater Sci: Mater Med (2012) 23: 835. doi:10.1007/s10856-011-4542-x

Abstract

Being able to control the behaviour of osteoblast-like cells on a surface may provide a genuine insight into the material surface characteristics and help in creating a successful coating/cell interface. The possibility of creating a micro-environment that can induce proliferation, differentiation and mineralisation of bone cells in vitro, by successfully combining both chemistry and topography of a micro-fabricated substrate is an area that requires a multi-disciplinary approach. Utilising sputter deposition, a process that lends itself to high processability, in conjunction with photolithography allowing for the creation of highly repeatable etched surfaces, we aim to provide a successful combination of chemistry and topography. Correlating the substrate conditions with resultant osteoblast biological function and activity can ultimately be used with a view to modulating the behavior of osteoblast-like cells in vitro.

Copyright information

© Springer Science+Business Media, LLC 2012