Article

Journal of Materials Science: Materials in Medicine

, Volume 23, Issue 3, pp 835-851

Osteoblast-like cell response to calcium phosphate coating chemistry and morphology on etched silicon surfaces

  • George A. BurkeAffiliated withNorthern Ireland Bioengineering Centre, University of Ulster Email author 
  • , Chris J. ReaAffiliated withNorthern Ireland Bioengineering Centre, University of Ulster
  • , Fergal G. HorganAffiliated withNorthern Ireland Bioengineering Centre, University of Ulster
  • , Marie TurkingtonAffiliated withNorthern Ireland Bioengineering Centre, University of Ulster
  • , Adrian R. BoydAffiliated withNorthern Ireland Bioengineering Centre, University of Ulster
  • , Brian J. MeenanAffiliated withNorthern Ireland Bioengineering Centre, University of Ulster

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Abstract

Being able to control the behaviour of osteoblast-like cells on a surface may provide a genuine insight into the material surface characteristics and help in creating a successful coating/cell interface. The possibility of creating a micro-environment that can induce proliferation, differentiation and mineralisation of bone cells in vitro, by successfully combining both chemistry and topography of a micro-fabricated substrate is an area that requires a multi-disciplinary approach. Utilising sputter deposition, a process that lends itself to high processability, in conjunction with photolithography allowing for the creation of highly repeatable etched surfaces, we aim to provide a successful combination of chemistry and topography. Correlating the substrate conditions with resultant osteoblast biological function and activity can ultimately be used with a view to modulating the behavior of osteoblast-like cells in vitro.