Influence of hyaluronic acid on bacterial and fungal species, including clinically relevant opportunistic pathogens

  • Andrea Ardizzoni
  • Rachele G. Neglia
  • Maria C. Baschieri
  • Claudio Cermelli
  • Manuela Caratozzolo
  • Elena Righi
  • Beniamino Palmieri
  • Elisabetta Blasi
Article

DOI: 10.1007/s10856-011-4408-2

Cite this article as:
Ardizzoni, A., Neglia, R.G., Baschieri, M.C. et al. J Mater Sci: Mater Med (2011) 22: 2329. doi:10.1007/s10856-011-4408-2

Abstract

Hyaluronic acid (HA) has several clinical applications (aesthetic surgery, dermatology, orthopaedics and ophtalmology). Following recent evidence, suggesting antimicrobial and antiviral properties for HA, we investigated its effects on 15 ATCC strains, representative of clinically relevant bacterial and fungal species. The in vitro system employed allowed to assess optical density of broth cultures as a measure of microbial load in a time-dependent manner. The results showed that different microbial species and, sometimes, different strains belonging to the same species, are differently affected by HA. In particular, staphylococci, enterococci, Streptococcus mutans, two Escherichia coli strains, Pseudomonas aeruginosa, Candida glabrata and C. parapsilosis displayed a HA dose-dependent growth inhibition; no HA effects were detected in E. coli ATCC 13768 and C. albicans; S. sanguinis was favoured by the highest HA dose. Therefore, the influence of HA on bacteria and fungi warrants further studies aimed at better establishing its relevance in clinical applications.

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Andrea Ardizzoni
    • 1
  • Rachele G. Neglia
    • 1
  • Maria C. Baschieri
    • 1
  • Claudio Cermelli
    • 1
  • Manuela Caratozzolo
    • 1
  • Elena Righi
    • 1
  • Beniamino Palmieri
    • 2
  • Elisabetta Blasi
    • 3
    • 4
  1. 1.Dipartimento di Scienze di Sanità PubblicaUniversità di Modena e Reggio EmiliaModenaItaly
  2. 2.Dipartimento di Chirurgia GeneraleUniversità di Modena e Reggio EmiliaModenaItaly
  3. 3.Dipartimento di Laboratori, Anatomia Patologica e Medicina LegaleUniversità di Modena e Reggio EmiliaModenaItaly
  4. 4.Istituti Biologici (2° piano)ModenaItaly