Journal of Materials Science: Materials in Medicine

, Volume 22, Issue 9, pp 1993–2004

Reactive calcium-phosphate-containing poly(ester-co-ether) methacrylate bone adhesives: setting, degradation and drug release considerations

  • Xin Zhao
  • Irwin Olsen
  • Jonathan Pratten
  • Jonathan C. Knowles
  • Anne M. Young
Article

DOI: 10.1007/s10856-011-4378-4

Cite this article as:
Zhao, X., Olsen, I., Pratten, J. et al. J Mater Sci: Mater Med (2011) 22: 1993. doi:10.1007/s10856-011-4378-4

Abstract

This study has investigated novel bone adhesives consisting of fluid photo-polymerizable poly(lactide-co-propylene glycol-co-lactide)dimethacrylate (PGLA-DMA) mixed with systematically varying fillers of β-tricalcium phosphate (β-TCP) and monocalcium phosphate monohydrate (MCPM), for the delivery of an antibacterial drug chlorhexidine (CHX). All formulations were found to polymerize fully within 200 s after exposure to blue light. In addition, water sorption by the polymerized materials catalyzed varying filler conversion to dicalcium phosphate (DCP) (i.e. brushite and monetite). With greater DCP levels, faster degradation was observed. Moreover, increase in total filler content enhanced CHX release, associated with higher antibacterial activity. These findings thus suggest that such rapid-setting and degradable adhesives with controllable drug delivery property could have potential clinical value as bone adhesives with antibacterial activity.

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Xin Zhao
    • 1
  • Irwin Olsen
    • 1
  • Jonathan Pratten
    • 2
  • Jonathan C. Knowles
    • 1
    • 3
  • Anne M. Young
    • 1
  1. 1.Biomaterials and Tissue Engineering Research DepartmentUCL Eastman Dental InstituteLondonUK
  2. 2.Microbial Diseases Research DepartmentUCL Eastman Dental InstituteLondonUK
  3. 3.WCU Research Centre of Nanobiomedical ScienceDankook UniversityCheonan-siSouth Korea