Journal of Materials Science: Materials in Medicine

, Volume 21, Issue 10, pp 2853–2859

Bone regeneration with glass ceramic implants and calcium phosphate cements in a rabbit cranial defect model

  • Gerlind Schneider
  • Karin Blechschmidt
  • Dirk Linde
  • Peter Litschko
  • Thomas Körbs
  • Eggert Beleites
Article

DOI: 10.1007/s10856-010-4143-0

Cite this article as:
Schneider, G., Blechschmidt, K., Linde, D. et al. J Mater Sci: Mater Med (2010) 21: 2853. doi:10.1007/s10856-010-4143-0

Abstract

Hydroxyapatite cement (BoneSource®) and brushite calcium phosphate cement (chronOS™ Inject) were tested for fixation of glass ceramic implants (Bioverit®) in experimentally created cranial defects in 24 adult New Zealand White rabbits. Aim of the in vivo study was to assess and compare the biocompatibility and osseointegration of the implanted materials. Macroscopic and histological evaluations were performed 1 month, 3 months, and 6 months postoperatively. All implanted materials were well tolerated by the surrounding tissue. Both bone cements exhibited osteoconductive properties. Differences could be detected regarding to the rates of cement resorption and new bone formation. The brushite cement was resorbed faster than the hydroxyapatite cement. The chronOS™ Inject samples exhibited a higher rate of connective tissue formation and an insufficient osseointegration. BoneSource® was replaced by bone with minimal invasion of connective tissue. New bone formation occurred faster compared to the chronOS™ Inject group. Bioverit® implants fixed with BoneSource® were successfully osseointegrated.

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Gerlind Schneider
    • 1
  • Karin Blechschmidt
    • 1
  • Dirk Linde
    • 1
  • Peter Litschko
    • 2
  • Thomas Körbs
    • 2
  • Eggert Beleites
    • 1
  1. 1.Department of Otorhinolaryngology, Faculty of MedicineFriedrich Schiller UniversityJenaGermany
  2. 2.3di GmbHJenaGermany