, Volume 21, Issue 6, pp 1969-1978
Date: 16 Mar 2010

Electro-spinning of PLGA/PCL blends for tissue engineering and their biocompatibility

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Abstract

In this study, an electro-spun co-polymer PLGA/PCL blend was fabricated using various percentages of PLGA in the blend PLGA/PCL solutions. The PLGA/PCL ratios used to fabricate the electrospun fibrous mats were reflected in the FT-IR (Fourier Transform Infrared Spectroscopy) data. Experimental results from the MTT assay showed that the biocompatibility of the electro-spun co-polymer increased at increasing percentages of PLGA. In vitro cells adhesion and proliferation of fibroblast cells on electro-spun mats were characterized by SEM morphology. In addition, we found that increasing PLGA concentrations affected the mechanical properties of electro-spun membranes and increased the biocompatibility of PLGA/PCL electro-spun fibrous mats.