Journal of Materials Science: Materials in Medicine

, Volume 21, Issue 6, pp 1969–1978

Electro-spinning of PLGA/PCL blends for tissue engineering and their biocompatibility

Authors

  • Nguyen Thi Hiep
    • Department of Biomedical Engineering and Materials, College of MedicineSoonchunhyang University
    • Department of Biomedical Engineering and Materials, College of MedicineSoonchunhyang University
Article

DOI: 10.1007/s10856-010-4048-y

Cite this article as:
Hiep, N.T. & Lee, B. J Mater Sci: Mater Med (2010) 21: 1969. doi:10.1007/s10856-010-4048-y

Abstract

In this study, an electro-spun co-polymer PLGA/PCL blend was fabricated using various percentages of PLGA in the blend PLGA/PCL solutions. The PLGA/PCL ratios used to fabricate the electrospun fibrous mats were reflected in the FT-IR (Fourier Transform Infrared Spectroscopy) data. Experimental results from the MTT assay showed that the biocompatibility of the electro-spun co-polymer increased at increasing percentages of PLGA. In vitro cells adhesion and proliferation of fibroblast cells on electro-spun mats were characterized by SEM morphology. In addition, we found that increasing PLGA concentrations affected the mechanical properties of electro-spun membranes and increased the biocompatibility of PLGA/PCL electro-spun fibrous mats.

Copyright information

© Springer Science+Business Media, LLC 2010