Journal of Materials Science: Materials in Medicine

, Volume 20, Issue 10, pp 2043–2051

Design of porous polymeric scaffolds by gas foaming of heterogeneous blends

  • A. Salerno
  • M. Oliviero
  • E. Di Maio
  • S. Iannace
  • P. A. Netti
Article

DOI: 10.1007/s10856-009-3767-4

Cite this article as:
Salerno, A., Oliviero, M., Di Maio, E. et al. J Mater Sci: Mater Med (2009) 20: 2043. doi:10.1007/s10856-009-3767-4

Abstract

One of the challenges in tissue engineering scaffold design is the realization of structures with a pre-defined multi-scaled porous network. Along this line, this study aimed at the design of porous scaffolds with controlled porosity and pore size distribution from blends of poly(ε-caprolactone) (PCL) and thermoplastic gelatin (TG), a thermoplastic natural material obtained by de novo thermoplasticization of gelatin. PCL/TG blends with composition in the range from 40/60 to 60/40 (w/w) were prepared by melt mixing process. The multi-phase microstructures of these blends were analyzed by scanning electron microscopy and dynamic mechanical analysis. Furthermore, in order to prepare open porous scaffolds for cell culture and tissue replacement, the TG and PCL were selectively extracted from the blends by the appropriate combination of solvent and extraction parameters. Finally, with the proposed combination of gas foaming and selective polymer extraction technologies, PCL and TG porous materials with multi-scaled and highly interconnected porosities were designed as novel scaffolds for new-tissue regeneration.

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • A. Salerno
    • 1
    • 2
  • M. Oliviero
    • 3
  • E. Di Maio
    • 1
  • S. Iannace
    • 3
  • P. A. Netti
    • 1
    • 2
  1. 1.Department of Materials and Production Engineering & Interdisciplinary Research Centre on Biomaterials (CRIB)University of Naples Federico IINaplesItaly
  2. 2.Italian Institute of Technology (IIT)GenoaItaly
  3. 3.Institute of Composite and Biomedical MaterialsNational Research Council of ItalyNaplesItaly

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