Article

Journal of Materials Science: Materials in Medicine

, Volume 19, Issue 5, pp 2241-2246

Injectability evaluation of tricalcium phosphate bone cement

  • Hugo Leonardo Rocha AlvesAffiliated withDepartment of Materials Science and Engineering, Federal University of Rio Grande do Sul Email author 
  • , Luis A. dos SantosAffiliated withDepartment of Materials Science and Engineering, Federal University of Rio Grande do Sul
  • , Carlos P. BergmannAffiliated withDepartment of Materials Science and Engineering, Federal University of Rio Grande do Sul

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Abstract

Calcium phosphate cements are biomaterials made from a mixture of calcium phosphate powder in aqueous solutions that forms a paste that reacts at the body temperature and hardens as a result of precipitation reactions. These cements are commonly used in dentistry and orthopedic bone filling surgeries, which require extremely invasive procedures. The challenge consists in formulating an injectable paste by additives incorporation. In this work, three different additives (carboxymethylcellulose, agar polymer and sodium alginate) were incorporated to tricalcium phosphate, in concentrations of 0.4, 0.8, 1.6, 3.2 and 6.4 wt.%. Injectability was evaluated through a new method developed for this purpose. Results showed that it was possible to obtain injectable compositions of α-tricalcium phosphate cement. It was verified that the injectability depends on the rheological behavior of the pastes and injection time. In this study, pastes with viscosity suitable for good homogenization and injection were obtained.