Journal of Materials Science: Materials in Medicine

, Volume 19, Issue 2, pp 847–854

Electrospun nanofibers immobilized with collagen for neural stem cells culture

Authors

  • Wensheng Li
    • Department of Neurosurgery3rd Affiliated Hospital of SUN YAT-SEN University
    • Department of Neurosurgery3rd Affiliated Hospital of SUN YAT-SEN University
  • Hui Wang
    • Department of Neurosurgery3rd Affiliated Hospital of SUN YAT-SEN University
  • Dejin Shi
    • Department of Neurosurgery3rd Affiliated Hospital of SUN YAT-SEN University
  • Chaofeng Liang
    • Department of Neurosurgery3rd Affiliated Hospital of SUN YAT-SEN University
  • Zhuopeng Ye
    • Department of Neurosurgery3rd Affiliated Hospital of SUN YAT-SEN University
  • Feng Qing
    • Department of Neurosurgery3rd Affiliated Hospital of SUN YAT-SEN University
  • Jin Gong
    • Department of Neurosurgery3rd Affiliated Hospital of SUN YAT-SEN University
Article

DOI: 10.1007/s10856-007-3087-5

Cite this article as:
Li, W., Guo, Y., Wang, H. et al. J Mater Sci: Mater Med (2008) 19: 847. doi:10.1007/s10856-007-3087-5

Abstract

Fibrous mats via electrospinning have been widely applied in tissue engineering. In this work, nanofibers were prepared via electrospinning from polymer with different content of carboxyl groups. A natural material, collagen, was then immobilized onto the nanofiber surface by N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC)/N-Hydroxysuccinimide (NHS) activation process. It was found that the immobilization degree of collagen could be facilely modulated. The obtained collagen-modified nanofibers were used for neural stem cells culture, and unmodified nanofibers were used as a control. Results indicated that the modification of collagen could enhance the attachment and viability of the cultured neural stem cells.

Copyright information

© Springer Science+Business Media, LLC 2007