Preparation of DHAQ-loaded mPEG-PLGA-mPEG nanoparticles and evaluation of drug release behaviors in vitro/in vivo
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
This study describes the preparation and the evaluation of biodegradation monomethoxy (polyethylene glycol)-poly (lactide-co-glycolide)-monomethoxy (polyethyleneglycol) (mPEG-PLGA-mPEG, PELGE) nanoparticles (PELGE-NP) containing mitoxantrone (DHAQ) as a model drug. PELGE copolymers with various molar ratios of lactic to glycolic acid and different molecular weights and various content mPEG were synthesized by ring-opening polymerization. mPEG with weight-average molecular weight (Mw) 2000 or 5000 was introduced as a hydrophilic segment into a hydrophobic PLGA. A double emulsion method with dextran70 as stabilizer in the external aqueous phase was used to prepare the nanoparticles. The drug entrapment efficiencies were more than 80% and the mean diameters of the nanoparticles were less than 200 nm. Various PELGE was studied as biodegradable drug carriers and there in vitro/in vivo release profiles were examined. It was found that drug loading, polymer molecular weight, copolymer composition and end group modifications were critical factors affecting the in vitro/in vivo release properties. The amount of drug released increased as the mPEG contents increased and the molar ratios of lactic acid decreased in vitro. The intravenous (i.v.) administration of mPEG-PLGA–mPEG nanoparticles of DHAQ in mice resulted in prolonged DHAQ residence in systemic blood circulation compared to the intravenous administration of PLGA nanoparticles.
- Y. I. JEONG and J. W. NAH, J. Appl. Polym. Sci. 80 (2001) 2228. CrossRef
- J. Y. YOON, http://www.nanotech.orkr/younjung.doc.04/01/2002.
- S. M. LI, in Degradable Polymers: Principles and Applications (Chapman and Hall, London, 1995) p. 43.
- R. GREF and A. DOMB, Adv. Drug. Deliv. Rev. 16 (1995) 215. CrossRef
- N. V. MAJETI and R. KUMAR, J. Pharm. Pharmaceut. Sci. 3 (2000) 234.
- K. AVGOUSTAKIS and D. S. ITHAKISSIOS, J. Contr. Rel. 79 (2002) 123. CrossRef
- E. CHIOTELIS and J. G. MCAFEE, Int. J. Nucl. Med. Biol. 4 (1977) 29. CrossRef
- G. SPENLEHAUER and J. P. BENOIT, Biomaterials 10 (1989) 557. CrossRef
- R. H. MULLER and O. KAYSER, Adv. Drug. Deliv. Rev. 47 (2001) 3. CrossRef
- M. L. HANS and A. M. LOWMAN, Curr. Opin. Solid State Mat. Sci. 6 (2002) 319. CrossRef
- T. REIHS and M. MULLER, J. Colloid. Interface Sci. 271 (2004) 69. CrossRef
- A. J. RAJEEV, Biomaterials 21 (2000) 2475. CrossRef
- R. GREF and R. LANGER, Science 263 (1994) 1600.
- H. FESSI and S. BENITA, Int. J. Pharm. 55 (1989) R1. CrossRef
- J. W. FONG and H. V. MAULDING, J. Contr. Rel. 3 (1986) 119. CrossRef
- D. BAZILE and M. VEILLARD, J. Pharm. Sci. 84 (1995) 493.
- J. W. NAH and C. S. CHO, J. Polym. Sci. B : Polym. Phys. 36 (1998) 415. CrossRef
- M. VITTAZ and G. SENLEHAUER, Biomaterials 17 (1996) 1575. CrossRef
- Preparation of DHAQ-loaded mPEG-PLGA-mPEG nanoparticles and evaluation of drug release behaviors in vitro/in vivo
Journal of Materials Science: Materials in Medicine
Volume 17, Issue 6 , pp 509-516
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers
- Additional Links
- Industry Sectors