Journal of Materials Science: Materials in Medicine

, Volume 17, Issue 2, pp 161–167

In vitro apatite forming ability of type I collagen hydrogels containing bioactive glass and silica sol-gel particles

  • David Eglin
  • Sonia Maalheem
  • Jacques Livage
  • Thibaud Coradin
Article

DOI: 10.1007/s10856-006-6820-6

Cite this article as:
Eglin, D., Maalheem, S., Livage, J. et al. J Mater Sci: Mater Med (2006) 17: 161. doi:10.1007/s10856-006-6820-6

Abstract

Type I collagen hydrogel containing bioactive glass (CaO-P2O5-SiO2) and silica sol-gel micrometric particles were prepared and their in vitroapatite-forming ability in simulated body fluid assessed. X-ray diffraction and scanning electron microscopy analysis showed that bioactive glass particles entrapment in collagen matrix did not inhibit calcium phosphate formation and induced morphology variations on the crystalline phase precipitated on the hydrogel surface. The silica—collagen hydrogel composite precipitated calcium phosphate whereas silica particles and collagen hydrogel alone did not, indicating a possible synergetic effect between collagen and silica on the apatite-forming ability. Mechanisms of calcium phosphate precipitation and its relevance to biomaterial development are discussed.

Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  • David Eglin
    • 1
  • Sonia Maalheem
    • 1
  • Jacques Livage
    • 1
  • Thibaud Coradin
    • 1
  1. 1.Laboratoire de Chimie de la Matière Condensée, CNRS-UMR 7574Université Pierre et Marie CurieParisFrance