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Reactive nanolayers for physiologically compatible microsystem packaging

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Abstract

This paper described a novel physiologically compatible wafer bonding technique for bio-microelectromechanical systems (bio-MEMS) packaging. Room temperature bonding was performed between Parylene-C and silicon wafers with a thin Parylene-C coating using reactive Ni/Al nanofilms as localized heaters. Live NIH 3T3 mouse fibroblast cells were encapsulated in the package and they survived the bonding process owing to the localization of heating. A numerical model was developed to predict the temperature evolutions in the parylene layers, silicon wafer and the encapsulated liquid during the bonding process. The simulation results were in agreement with the cell encapsulation experiment revealing that localized heating occurred in this bonding approach. This study proved the feasibility of reactive nanofilm bonding technique for broad applications in packaging bio-MEMS and microfluidic systems.

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Authors and Affiliations

  1. Department of Electrical Engineering, Arizona State University, Tempe, AZ, 85287, USA

    Xiaotun Qiu, David Welch, Jennifer Blain Christen, Jie Zhu & Hongyu Yu

  2. School of Earth and Space Exploration, Arizona State University, Tempe, AZ, 85287, USA

    Jon Oiler, Ziyu Wang & Hongyu Yu

  3. Department of Mechanical and Aerospace Engineering, Arizona State University, Tempe, AZ, 85287, USA

    Cunjiang Yu

Authors
  1. Xiaotun Qiu
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  2. David Welch
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  3. Jennifer Blain Christen
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  4. Jie Zhu
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  5. Jon Oiler
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  6. Cunjiang Yu
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  7. Ziyu Wang
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  8. Hongyu Yu
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Correspondence to Xiaotun Qiu.

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Qiu, X., Welch, D., Christen, J.B. et al. Reactive nanolayers for physiologically compatible microsystem packaging. J Mater Sci: Mater Electron 21, 562–566 (2010). https://doi.org/10.1007/s10854-009-9957-5

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  • DOI: https://doi.org/10.1007/s10854-009-9957-5

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