Phase solubility and FTIR-ATR studies of idebenone/sulfobutyl ether β-cyclodextrin inclusion complex

  • C. Cannavà
  • V. Crupi
  • M. Guardo
  • D. Majolino
  • R. Stancanelli
  • S. Tommasini
  • C. A. Ventura
  • V. Venuti
Original Article

DOI: 10.1007/s10847-012-0110-3

Cite this article as:
Cannavà, C., Crupi, V., Guardo, M. et al. J Incl Phenom Macrocycl Chem (2013) 75: 255. doi:10.1007/s10847-012-0110-3

Abstract

The favourable accessibility offered by sulfobutyl ether β-cyclodextrin (SBE-β-CD) for the complexation with idebenone (IDE) has been probed, as a function of temperature, in liquid state, by phase solubility study, and, in solid state, by FTIR-ATR technique. The phase solubility results indicated the formation of a IDE/SBE-β-CD inclusion complex with 1:1 molar ratio (AL type diagram), whose apparent stability constants at T = 300, 310, and 320 K have been estimated according to the Higuchi–Connors method. The formation of the inclusion complex has been confirmed on a freeze-dried and a co-precipitated product by FTIR-ATR spectroscopy, monitoring the changes induced by complexation on some characteristic vibrational bands of IDE. Quantitative studies, performed in a wide T range, from T = 250 K to T = 340 K, allowed us to extract information on the effect of temperature on the different hydrogen-bonded environments involving host, guest, and crystallization water molecules. Again, complexation is proved to enhance the stability of the guest, at least in the explored T range.

Keywords

Idebenone Sulfobutyl ether β-cyclodextrin Inclusion complex Phase-solubility FTIR-ATR spectroscopy 

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • C. Cannavà
    • 1
  • V. Crupi
    • 2
  • M. Guardo
    • 1
  • D. Majolino
    • 2
  • R. Stancanelli
    • 1
  • S. Tommasini
    • 1
  • C. A. Ventura
    • 1
  • V. Venuti
    • 2
  1. 1.Dipartimento Farmaco-Chimico, Facoltà di FarmaciaUniversità di MessinaMessinaItaly
  2. 2.Dipartimento di Fisica, Facoltà di Scienze MM. FF. NN.Università di MessinaMessinaItaly

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