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Preparation and characterization of inclusion complexes of topotecan with sulfonatocalixarene

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Abstract

Inclusion complex of sulfonatocalix[4]arene (SC4A) with topotecan (TPT) was prepared, and its inclusion complexation behaviors, such as stoichiometry, complex stability constants, and inclusion mode, were investigated by means of UV/Vis spectroscopy, DSC, and 2D NMR. The obtained results show that the quinoline ring and the dimethylaminomethyl group of TPT can be efficiently encapsulated in SC4A, and the complex is more soluble than free TPT.

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Acknowledgments

We thank 973 Program (2006CB932900) and NNSFC (20932004 and 20721062) for financial support.

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  1. Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, People’s Republic of China

    Guo-Song Wang, Heng-Yi Zhang, Fei Ding & Yu Liu

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  1. Guo-Song Wang
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  2. Heng-Yi Zhang
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Correspondence to Yu Liu.

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Wang, GS., Zhang, HY., Ding, F. et al. Preparation and characterization of inclusion complexes of topotecan with sulfonatocalixarene. J Incl Phenom Macrocycl Chem 69, 85–89 (2011). https://doi.org/10.1007/s10847-010-9817-1

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  • DOI: https://doi.org/10.1007/s10847-010-9817-1

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