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Preparation and physicochemical characterization of carbamazepine (CBMZ): para-sulfonated calix[n]arene inclusion complexes

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Abstract

The formation of inclusion complexes with para-sulfonated calix[n]arene (PSC[n]A) was studied for carbamazepine (CBMZ), a poorly water soluble anticonvulsant drug. The effect of PSC[4]A and PSC[6]A on aqueous solubility of carbamazepine was studied extensively. The complete complexation of the drug was achieved after 48 h of shaking with PSC[n]A in water and evaporation of water to get solid complex. The interaction between PSC[n]A and CBMZ in solid state inclusion complexes was accomplished by aqueous phase solubility studies, HPLC, DSC, PXRD, FTIR, UV–Vis, and FT-Raman spectroscopy. The solubility of CBMZ increases as a function of PSC[n]A concentration. The results of the two phase solubility experiments are in good conformity to signify the formation of 1:1 (PSC[6]A:CBMZ) and 2:1 PSC[4]A:CBMZ complexes. The order of dissolution rate of CBMZ is inclusion complex > physical mixture > drug alone. The purpose of this study was to enhance solubility resulting in high dissolution rate and bioavailability of this essentially water insoluble drug.

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Acknowledgement

Financial assistance from UGC, New Delhi is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, School of Sciences, Gujarat University, Navrangpura, Ahmedabad, 380 009, Gujarat, India

    Jayesh G. Panchal, Ravindra V. Patel & Shobhana K. Menon

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  1. Jayesh G. Panchal
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  2. Ravindra V. Patel
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  3. Shobhana K. Menon
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Correspondence to Shobhana K. Menon.

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Panchal, J.G., Patel, R.V. & Menon, S.K. Preparation and physicochemical characterization of carbamazepine (CBMZ): para-sulfonated calix[n]arene inclusion complexes. J Incl Phenom Macrocycl Chem 67, 201–208 (2010). https://doi.org/10.1007/s10847-009-9698-3

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