Journal of Computational Neuroscience

, Volume 34, Issue 2, pp 211–229

Relating ion channel expression, bifurcation structure, and diverse firing patterns in a model of an identified motor neuron

  • Marco A. Herrera-Valdez
  • Erin C. McKiernan
  • Sandra D. Berger
  • Stefanie Ryglewski
  • Carsten Duch
  • Sharon Crook
Article

DOI: 10.1007/s10827-012-0416-6

Cite this article as:
Herrera-Valdez, M.A., McKiernan, E.C., Berger, S.D. et al. J Comput Neurosci (2013) 34: 211. doi:10.1007/s10827-012-0416-6

Abstract

Neurons show diverse firing patterns. Even neurons belonging to a single chemical or morphological class, or the same identified neuron, can display different types of electrical activity. For example, motor neuron MN5, which innervates a flight muscle of adult Drosophila, can show distinct firing patterns under the same recording conditions. We developed a two-dimensional biophysical model and show that a core complement of just two voltage-gated channels is sufficient to generate firing pattern diversity. We propose Shab and DmNav to be two candidate genes that could encode these core currents, and find that changes in Shab channel expression in the model can reproduce activity resembling the main firing patterns observed in MN5 recordings. We use bifurcation analysis to describe the different transitions between rest and spiking states that result from variations in Shab channel expression, exposing a connection between ion channel expression, bifurcation structure, and firing patterns in models of membrane potential dynamics.

Keywords

Bifurcation Electrophysiology Excitability Firing pattern Gene expression Ion channels 

Supplementary material

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10827_2012_416_MOESM2_ESM.eps (20 kb)
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10827_2012_416_MOESM3_ESM.eps (457 kb)
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10827_2012_416_MOESM4_ESM.eps (2.6 mb)
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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Marco A. Herrera-Valdez
    • 1
    • 2
    • 3
    • 4
  • Erin C. McKiernan
    • 1
  • Sandra D. Berger
    • 5
  • Stefanie Ryglewski
    • 5
    • 6
  • Carsten Duch
    • 5
    • 6
  • Sharon Crook
    • 7
  1. 1.Institute of Interdisciplinary ResearchUniversity of Puerto Rico at CayeyCayeyUSA
  2. 2.Department of Mathematics and PhysicsUniversity of Puerto Rico at CayeyCayeyUSA
  3. 3.Department of MathematicsUniversity of ArizonaTucsonUSA
  4. 4.Evelyn F. McKnight Brain InstituteUniversity of ArizonaTucsonUSA
  5. 5.School of Life SciencesArizona State UniversityTempeUSA
  6. 6.Johannes Gutenberg University MainzInstitute for Zoology/NeurobiologyMainzGermany
  7. 7.School of Mathematical and Statistical SciencesArizona State UniversityTempeUSA

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