Journal of Computer-Aided Molecular Design

, Volume 26, Issue 1, pp 57–67

Does your model weigh the same as a Duck?

Perspective

DOI: 10.1007/s10822-011-9530-1

Cite this article as:
Jain, A.N. & Cleves, A.E. J Comput Aided Mol Des (2012) 26: 57. doi:10.1007/s10822-011-9530-1

Abstract

Computer-aided drug design is a mature field by some measures, and it has produced notable successes that underpin the study of interactions between small molecules and living systems. However, unlike a truly mature field, fallacies of logic lie at the heart of the arguments in support of major lines of research on methodology and validation thereof. Two particularly pernicious ones are cum hoc ergo propter hoc (with this, therefore because of this) and confirmation bias (seeking evidence that is confirmatory of the hypothesis at hand). These fallacies will be discussed in the context of off-target predictive modeling, QSAR, molecular similarity computations, and docking. Examples will be shown that avoid these problems.

Keywords

Correlation fallacyConfirmation biasQSARDockingOff-targetsHoly Grail

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Department of Bioengineering and Therapeutic Sciences, Helen Diller Family Comprehensive Cancer CenterUniversity of California, San FranciscoSan FranciscoUSA