Journal of Assisted Reproduction and Genetics

, Volume 30, Issue 3, pp 305–314

A review of 15 years of ovarian tissue bank activities

  • Marie-Madeleine Dolmans
  • Pascale Jadoul
  • Sébastien Gilliaux
  • Christiani A. Amorim
  • Valérie Luyckx
  • Jean Squifflet
  • Jacques Donnez
  • Anne Van Langendonckt
Fertility Preservation

DOI: 10.1007/s10815-013-9952-x

Cite this article as:
Dolmans, MM., Jadoul, P., Gilliaux, S. et al. J Assist Reprod Genet (2013) 30: 305. doi:10.1007/s10815-013-9952-x

Abstract

Purpose

To review 15 years of activities in ovarian tissue cryobanking from medical database files, including patient indications, histological evaluation and clinical characteristics.

Methods

Retrospective longitudinal analysis of data from an ovarian tissue bank in an academic hospital. Five hundred and eighty-two patients had their ovarian tissue cryobanked between April 1997 and January 2012. Analysis of cryobanking database: precryopreservation patient characteristics, indications and safety issues, laboratory files and postcryopreservation clinical data.

Results

Of the 582 patients who had their ovarian tissue cryopreserved, 106 patients donated for research purposes and 476 patients for fertility preservation and long-term cryopreservation. Clinical data analysis of the 476 patients revealed a mean age at the time of cryopreservation of 23 ± 8.5 years (range: 9 months – 39 years), with 96.2 % of subjects aged ≤35 years (n = 458). Among 391 cases of malignant disease, hematological malignancies (39.9 %, n = 156) and breast cancer (21.7 %, n = 85) were the two main indications. At histology, malignant cells were found in ovarian tissue from leukemia patients (n = 3) and non-Hodgkin’s lymphoma patients (n = 2). Eleven patients underwent autotransplantation, resulting in 5 live births and 1 ongoing pregnancy.

Conclusion

This is the largest and most comprehensive study to describe and analyze indications and clinical patient characteristics before and after ovarian tissue cryopreservation. The procedure is safe, easy and promising. The database concept is a useful tool in patient selection for autotransplantation.

Keywords

ChemotherapyCancerPremature ovarian failureOvarian tissue cryopreservationDatabaseMalignant cellsCryobank

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Marie-Madeleine Dolmans
    • 1
    • 2
  • Pascale Jadoul
    • 1
    • 2
  • Sébastien Gilliaux
    • 1
  • Christiani A. Amorim
    • 1
  • Valérie Luyckx
    • 1
    • 2
  • Jean Squifflet
    • 1
    • 2
  • Jacques Donnez
    • 1
    • 2
  • Anne Van Langendonckt
    • 1
  1. 1.Department of Gynecology, Institut de Recherche Expérimentale et Clinique (IREC)Université Catholique de LouvainBrusselsBelgium
  2. 2.Department of GynecologyCliniques Universitaires Saint LucBrusselsBelgium