, Volume 30, Issue 2, pp 197-202
Date: 05 Feb 2013

Mild ovarian stimulation for in vitro fertilization: one perspective from the USA

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To provide a perspective regarding mild ovarian stimulation, taking into account particular issues relevant in the United States


Literature review and editorial commentary


Mild ovarian stimulation for IVF has some proven and some theoretical advantages over conventional stimulation, such as lower risk of ovarian hyperstimulation syndrome and lower cost per fresh IVF cycle. However, cumulative live birth rate, including transfers from fresh and frozen embryos, is likely to be lower with mild stimulation. The cost-effectiveness of mild stimulation IVF in the United States has not been established.


Mild ovarian stimulation is an appropriate option to consider for certain patient groups or based on patient preference. However, significant potential disadvantages limit its widespread acceptability for patients in the United States at this time.


Although mild ovarian stimulation has some advantages, concerns regarding lower cumulative live birth rate and unproven cost-effectiveness currently limit its use in the United States.
Guest Editors: Ri-Cheng Chian & Jia-Yin Liu; Editor-in-Chief: David F. Albertini