Journal of Assisted Reproduction and Genetics

, Volume 30, Issue 7, pp 897–905

Impact of assisted reproduction treatments on Spanish newborns: report of 14,119 pregnancies

  • E. Ricciarelli
  • I. Bruna
  • V. Verdú
  • M. J. Torrelló
  • R. Herrer
  • J. M. Gris
  • G. Arroyo
  • F. Pérez-Millán
  • F. Del Río
  • M. Fernández-Sánchez
  • Y. Cabello
  • M. Ardoy
  • S. Fernández-Shaw
ASSISTED REPRODUCTION TECHNOLOGIES

DOI: 10.1007/s10815-013-0023-0

Cite this article as:
Ricciarelli, E., Bruna, I., Verdú, V. et al. J Assist Reprod Genet (2013) 30: 897. doi:10.1007/s10815-013-0023-0
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Abstract

Purpose

To investigate neonatal malformation, prematurity, and stillbirth in singleton and multiple pregnancies derived from different Assisted Reproductive Techniques (ART).

Methods

In this prospective cohort study data were collected, from private and public Spanish IVF units, during the years 2008 and 2009. During this period, 8,682 pregnancies were analysed from the initial 14,119 pregnancies reported. Pregnancies included in the study derived from IUI (n = 1,065), IVF (n = 838), ICSI (n = 5,080), FET (n = 1,404) and PGD (n = 295). This first analysis focuses primarily on neonatal malformation, prematurity, and stillbirth both in singleton and multiple pregnancies derived from different ART. Malformations were classified according to the WHO ICD 10 code.

Results

Malformations were found in 0.83 % of our newborns. No differences in malformations were observed between singletons or multiples independently of the ART used. There was a significant difference in prematurity rate among singletons depending on treatment but this association was not observed in multiple pregnancies. Stillbirth was significantly lower in singleton (0.72 %) than in multiple pregnancies (1.82 %).

Conclusions

The percentage of malformations observed in ART newborns was similar to the rate observed in the normally-conceived Spanish population. Multiplicity seems to be the most important factor associated with an increased incidence of newborn complications such as prematurity or stillbirth.

Keywords

ARTPregnancy outcomePerinatal outcomeMalformationsPrematurityStillbirth

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • E. Ricciarelli
    • 1
  • I. Bruna
    • 2
  • V. Verdú
    • 3
  • M. J. Torrelló
    • 4
  • R. Herrer
    • 5
  • J. M. Gris
    • 6
  • G. Arroyo
    • 7
  • F. Pérez-Millán
    • 8
  • F. Del Río
    • 9
  • M. Fernández-Sánchez
    • 10
  • Y. Cabello
    • 11
  • M. Ardoy
    • 8
  • S. Fernández-Shaw
    • 12
  1. 1.FIVMadridMadridSpain
  2. 2.Hospital Universitario Madrid-MonteprincipeMadridSpain
  3. 3.GINEFIVMadridSpain
  4. 4.Hospital QuirónBarcelonaSpain
  5. 5.IVI-MadridMadridSpain
  6. 6.Hospital Universitario Vall d’HebronBarcelonaSpain
  7. 7.Instituto Universitario DexeusBarcelonaSpain
  8. 8.Hospital Universitario Gregorio MarañonMadridSpain
  9. 9.Clínica CorachanBarcelonaSpain
  10. 10.IVI-SevillaSevillaSpain
  11. 11.Clínica RuberMadridSpain
  12. 12.URH- García del RealMadridSpain