Journal of Assisted Reproduction and Genetics

, Volume 29, Issue 11, pp 1227–1239

Assessment and treatment of repeated implantation failure (RIF)


DOI: 10.1007/s10815-012-9861-4

Cite this article as:
Simon, A. & Laufer, N. J Assist Reprod Genet (2012) 29: 1227. doi:10.1007/s10815-012-9861-4


Repeated implantation failure (RIF) is determined when embryos of good quality fail to implant following several in vitro fertilization (IVF) treatment cycles. Implantation failure is related to either maternal factors or embryonic causes. Maternal factors include uterine anatomic abnormalities, thrombophilia, non-receptive endometrium and immunological factors. Failure of implantation due to embryonic causes is associated with either genetic abnormalities or other factors intrinsic to the embryo that impair its ability to develop in utero, to hatch and to implant. New methods of time-lapse imaging of embryos and assessment of their metabolic functions may improve selection of embryos for transfer, and subsequent outcomes for IVF patients, as well as for those diagnosed with RIF. This review discusses the various causes associated with RIF and addresses appropriate treatments.


ImplantationRecurrent implantation failureRepeated implantation failureRIFIn vitro fertilizationIVF failure

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Obstetrics and Gynecology, In Vitro Fertilization Unit, Ein KeremHebrew University, Hadassah Medical CenterJerusalemIsrael