, Volume 29, Issue 11, pp 1227-1239
Date: 14 Sep 2012

Assessment and treatment of repeated implantation failure (RIF)

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Abstract

Repeated implantation failure (RIF) is determined when embryos of good quality fail to implant following several in vitro fertilization (IVF) treatment cycles. Implantation failure is related to either maternal factors or embryonic causes. Maternal factors include uterine anatomic abnormalities, thrombophilia, non-receptive endometrium and immunological factors. Failure of implantation due to embryonic causes is associated with either genetic abnormalities or other factors intrinsic to the embryo that impair its ability to develop in utero, to hatch and to implant. New methods of time-lapse imaging of embryos and assessment of their metabolic functions may improve selection of embryos for transfer, and subsequent outcomes for IVF patients, as well as for those diagnosed with RIF. This review discusses the various causes associated with RIF and addresses appropriate treatments.

Capsule Successful implantation depends on well functioning endometrium and healthy embryo. An abnormality in one or both these variables can cause repeat implantation failure. The condition should be assessed for its different causes and be treated accordingly.