Journal of Assisted Reproduction and Genetics

, Volume 28, Issue 6, pp 495–499

IVM is an alternative for patients with PCO after failed conventional IVF attempt

Authors

    • Department of Obstetrics & Gynecology, School of MedicineDokuz Eylul University Hospital
    • Division of Reproductive Endocrinology & IVF Unit
  • Muge Kovali
    • Department of Obstetrics & Gynecology, School of MedicineDokuz Eylul University Hospital
  • Fulya Aydiner
    • Department of Obstetrics & Gynecology, School of MedicineDokuz Eylul University Hospital
  • Sule Dogan
    • Department of Obstetrics & Gynecology, School of MedicineDokuz Eylul University Hospital
  • Seda S. Dogan
    • Department of Obstetrics & Gynecology, School of MedicineDokuz Eylul University Hospital
Assisted reproductive Technologies

DOI: 10.1007/s10815-011-9591-z

Cite this article as:
Gulekli, B., Kovali, M., Aydiner, F. et al. J Assist Reprod Genet (2011) 28: 495. doi:10.1007/s10815-011-9591-z

Abstract

Purpose

To determine if IVM of oocytes from unstimulated cycle is a treatment option for patients who did not deliver after standard IVF-ET.

Method

Twenty three women with PCO, thirteen of them with normal cycles and all <35 years old, who failed IVF served as their own control. During the control IVF cycle patients were stimulated with 1730.7 ± 639.5 IU recombinant FSH, a long Buserelin acetate protocol was used and embryo transfer was performed on day 2 or 3 after ICSI. After failed IVF immature oocytes were aspirated transvaginally from antral follicles during spontaneous menstrual cycle. Embryo transfer was performed 2 or 3 days later.

Result

11.4 ± 4.8 mature oocytes and 6.7 ± 3.2 embryos were produced with IVF, which served as the control, compared to 9.7 ± 4.5 mature oocytes and 6.2 ± 3.2 embryos with IVM. There was one clinical pregnancy in the IVF group which did not result in a live birth where as five singleton and one pair of twins with healthy live births and one miscarriage in the IVM group.

Conclusion

IVM does not involve ovarian stimulation with possible financial and health consequences. İt may be an useful treatment after unsuccessful IVF.

Keywords

IVMLive birth rateUnstimulated cycleUnsuccessful IVF attempt

Copyright information

© Springer Science+Business Media, LLC 2011