Journal of Assisted Reproduction and Genetics

, Volume 28, Issue 7, pp 583–589

Premature ovarian failure in nobox-deficient mice is caused by defects in somatic cell invasion and germ cell cyst breakdown

  • Agnieszka Lechowska
  • Szczepan Bilinski
  • Youngsok Choi
  • Yonghyun Shin
  • Malgorzata Kloc
  • Aleksandar Rajkovic
Gonadal Physiology and Disease

DOI: 10.1007/s10815-011-9553-5

Cite this article as:
Lechowska, A., Bilinski, S., Choi, Y. et al. J Assist Reprod Genet (2011) 28: 583. doi:10.1007/s10815-011-9553-5

Abstract

Purpose

To understand the mechanism of premature ovarian failure (POF).

Methods

The ultrastructural (electron microscopy) analysis of primordial ovarian follicles in Nobox deficient mice.

Results

We studied, for the first time, the fate of oogonia in embryonic (prenatal) mouse ovaries and showed that the abolishment of the transition from germ cell cysts to primordial follicles in the ovaries of Nobox deficient mice is caused by defects in germ cell cyst breakdown, leading to the formation of syncytial follicles instead of primordial follicles.

Conclusions

These results indicate that POF syndrome in Nobox deficient mice results from the faulty signaling between somatic and germ line components during embryonic development. In addition, the extremely unusual and abnormal presence of adherens junctions between unseparated oocytes within syncytial follicles indicates that faulty communication between somatic and germ cells is involved in, or leads to, abnormalities in the cell adhesion program.

Keywords

Premature ovarian failureNoboxHomeoboxOvaryGerm cells

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Agnieszka Lechowska
    • 1
  • Szczepan Bilinski
    • 1
  • Youngsok Choi
    • 2
  • Yonghyun Shin
    • 3
  • Malgorzata Kloc
    • 4
  • Aleksandar Rajkovic
    • 3
  1. 1.Institute of ZoologyJagiellonian UniversityKrakowPoland
  2. 2.Department of Biomedical SciencesCHA UniversitySeoulThe Republic of Korea
  3. 3.Magee Women’s Research Institute, Department of Obstetrics and Gynecology and Reproductive SciencesUniversity of PittsburghPittsburghUSA
  4. 4.Department of SurgeryThe Methodist Hospital and The Methodist Hospital Research InstituteHoustonUSA