Journal of Assisted Reproduction and Genetics

, Volume 28, Issue 7, pp 575–581

Frozen-thawed embryo transfer cycles: clinical outcomes of single and double blastocyst transfers

Authors

    • Vincent Obstetrics and Gynecology Service, Division of Reproductive Medicine and IVFMassachusetts General Hospital, Harvard Medical School
  • Sarah T. McLellan
    • Vincent Obstetrics and Gynecology Service, Division of Reproductive Medicine and IVFMassachusetts General Hospital, Harvard Medical School
  • Eric A. Macklin
    • Biostatistics CenterMassachusetts General Hospital, Harvard Medical School
  • Thomas L. Toth
    • Vincent Obstetrics and Gynecology Service, Division of Reproductive Medicine and IVFMassachusetts General Hospital, Harvard Medical School
  • Diane L. Wright
    • Vincent Obstetrics and Gynecology Service, Division of Reproductive Medicine and IVFMassachusetts General Hospital, Harvard Medical School
Assisted Reproduction Technologies

DOI: 10.1007/s10815-011-9551-7

Cite this article as:
Berin, I., McLellan, S.T., Macklin, E.A. et al. J Assist Reprod Genet (2011) 28: 575. doi:10.1007/s10815-011-9551-7

Abstract

Purpose

To evaluate clinical outcomes of frozen-thawed embryo transfer cycles when one or two blastocysts are transferred.

Methods

Retrospective chart review

Results

Two hundred forty-three frozen blastocyst transfer (FBT) cycles were analyzed. Clinical pregnancy rate (50.4% vs. 34.7%), live birth rate (45.8% vs. 30.6%), and twin live birth rate (19.3% vs. 0) were significantly higher in the double versus single FBT group, respectively (p < 0.05). Prior fresh cycle success with same-cohort embryos did not predict outcome of FBT cycle. When the fresh cycle was unsuccessful, there still was a significant increase in twinning when two frozen-thawed blastocysts were transferred.

Conclusions

Transferring two blastocysts during an FBT cycle resulted in higher live birth and twin live birth rates. Single FBT provided acceptable pregnancy rates for couples seeking to avoid a multiple pregnancy or for those having a single blastocyst stored. Interestingly, the outcome of fresh cycle with same-cohort embryos did not influence the outcome of frozen-thawed cycle.

Keywords

Frozen blastocyst transferFrozen cycle outcomeIVFMultiple pregnancyNumber of embryos to transfer

Copyright information

© Springer Science+Business Media, LLC 2011