, Volume 28, Issue 4, pp 369-374
Date: 13 Jan 2011

Use of the natural cycle and vitrification thawed blastocyst transfer results in better in-vitro fertilization outcomes

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To compare the IVF outcomes of vitrification-thawed blastocyst transfer cycles utilizing different endometrial preparation methods.


We retrospectively assessed IVF outcomes in 611 patients (648 cycles) who underwent blastocyst frozen embryo transfer (FET) between January 2007 and December 2009. All embryos had been cryopreserved by a vitrification method following a previous IVF cycle. Patients were prepared for transfer by using either the natural cycle (n = 310/Group 1), the natural cycle with ovulation induction employing human chorionic gonadotropin (n = 134/Group 2), or a hormonally manipulated artificial cycle with estrogen and progesterone supplementation (n = 204/Group 3).


Multivariate logistic regression analysis showed a significant difference in clinical pregnancy rate between Groups 3 (30.4%) and 1 (41.9%) (odds ratio [OR], 0.567; 95% confidence interval [CI], 0.379–0.847, P = 0.006) whereas the difference between Groups 2 and 1 was not significant (41.8% vs. 41.9%; OR, 0.683; 95% CI, 0.435–1.073; P = 0.098). Other significant variables affecting clinical pregnancy rate were the number of embryos transferred, the grade of transferred embryos, and maximal endometrial thickness.


The results showed that, using vitrification-thawed blastocyst transfer, employment of natural cycles with or without hCG treatment was associated with better outcomes than was the use of hormonally manipulated cycles.


During vitrified-thawed blastocyst transfer, the use of natural cycles with or without hCG treatment resulted in more favorable IVF outcomes than were noted when hormonally manipulated cycles were employed.
Presented at the 66th Annual Meeting of the American Society for Reproductive Medicine, Denver, CO, on October 24, 2010.
Woo Sik Lee and Tae Ki Yoon contributed equally to this work.