Overweight Men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
To evaluate if elevated male body mass influences success after assisted reproductive technologies
Retrospective study of 290 cycles.
Male body mass index greater than 25.0 kg/m2 was associated with significantly lower clinical pregnancy (53.2% vs. 33.6%). Multivariable logistic regression indicated that the likelihood of clinical pregnancy was decreased if the male partner was overweight after in vitro fertilization but not after intracytoplasmic sperm injection (odds ratios: 0.21 [0.07–0.69] vs. 0.75 [0.38–1.49], respectively) after adjustment for number of embryos transferred, sperm concentration, female age and body mass.
In this cohort, overweight status of the male partner was independently associated with decreased likelihood of clinical pregnancy after in vitro fertilization but not after intracytoplasmic sperm injection. A detrimental impact of higher male body mass was observed after adjusting for sperm concentration, suggesting that intracytoplasmic sperm injection may overcome some obesity related impairment of sperm-egg interaction.
- Stewart ST, Cutler DM, Rosen AB. Forecasting the effects of obesity and smoking on U.S. life expectancy. N Engl J Med. 2009;361:2252–60. CrossRef
- Olshansky SJ, Passaro DJ, Hershow RC, Layden J, Carnes BA, Brody J, et al. A potential decline in life expectancy in the United States in the 21st century. N Engl J Med. 2005;352:1138–45. CrossRef
- Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999–2004. JAMA. 2006;295:1549–55. CrossRef
- Wang Y, Beydoun MA. The obesity epidemic in the United States—gender, age, socioeconomic, racial/ethnic, and geographic characteristics: a systematic review and meta-regression analysis. Epidemiol Rev. 2007;29:6–28. CrossRef
- Obesity and reproduction: an educational bulletin. Fertil Steril 2008;90(5 Suppl):S21–S9.
- The ESHRE Capri Workshop Group. Nutrition and reproduction in women. Hum Reprod Update. 2006;12:193–207. CrossRef
- Polotsky AJ, Hailpern SM, Skurnick JH, Lo JC, Sternfeld B, Santoro N. Association of adolescent obesity and lifetime nulliparity-The Study of Women's Health Across the Nation (SWAN). Fertil Steril 2009.
- Ramlau-Hansen CH, Thulstrup AM, Nohr EA, Bonde JP, Sorensen TI, Olsen J. Subfecundity in overweight and obese couples. Hum Reprod. 2007;22:1634–7. CrossRef
- Speakman JR, Djafarian K, Stewart J, Jackson DM. Assortative mating for obesity. Am J Clin Nutr. 2007;86:316–23.
- Silventoinen K, Kaprio J, Lahelma E, Viken RJ, Rose RJ. Assortative mating by body height and BMI: Finnish twins and their spouses. Am J Hum Biol. 2003;15:620–7. CrossRef
- Sallmen M, Sandler DP, Hoppin JA, Blair A, Baird DD. Reduced fertility among overweight and obese men. Epidemiology. 2006;17:520–3. CrossRef
- Nguyen RH, Wilcox AJ, Skjaerven R, Baird DD. Men's body mass index and infertility. Hum Reprod. 2007;22:2488–93. CrossRef
- Hammoud AO, Wilde N, Gibson M, Parks A, Carrell DT, Meikle AW. Male obesity and alteration in sperm parameters. Fertil Steril. 2008;90:2222–5. CrossRef
- Jensen TK, Andersson AM, Jorgensen N, Andersen AG, Carlsen E, Petersen JH, et al. Body mass index in relation to semen quality and reproductive hormones among 1, 558 Danish men. Fertil Steril. 2004;82:863–70. CrossRef
- Hofny ER, Ali ME, Abdel-Hafez HZ, El-Dien Kamal E, Mohamed EE, Abd El-Azeem HG et al. Semen parameters and hormonal profile in obese fertile and infertile males. Fertil Steril 2009.
- Kort HI, Massey JB, Elsner CW, Mitchell-Leef D, Shapiro DB, Witt MA, et al. Impact of body mass index values on sperm quantity and quality. J Androl. 2006;27:450–2. CrossRef
- Magnusdottir EV, Thorsteinsson T, Thorsteinsdottir S, Heimisdottir M, Olafsdottir K. Persistent organochlorines, sedentary occupation, obesity and human male subfertility. Hum Reprod. 2005;20:208–15. CrossRef
- Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril 2009.
- Vermeulen A, Kaufman JM, Deslypere JP, Thomas G. Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men. J Clin Endocrinol Metab. 1993;76:1140–6. CrossRef
- Obesity: Preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000;894:i–xii, 1–253.
- Polotsky AJ, Daif JL, Jindal S, Lieman HJ, Santoro N, Pal L. Serum progesterone on the day of human chorionic gonadotropin administration predicts clinical pregnancy of sibling frozen embryos. Fertil Steril. 2009;92:1880–5. CrossRef
- Devroey P, Van Steirteghem A. A review of ten years experience of ICSI. Hum Reprod Update. 2004;10:19–28. CrossRef
- Kurth T, Walker AM, Glynn RJ, Chan KA, Gaziano JM, Berger K, et al. Results of multivariable logistic regression, propensity matching, propensity adjustment, and propensity-based weighting under conditions of nonuniform effect. Am J Epidemiol. 2006;163:262–70. CrossRef
- Rogers J, Mitchell Jr GW. The relation of obesity to menstrual disturbances. N Engl J Med. 1952;247:53–5. CrossRef
- Grodstein F, Goldman MB, Cramer DW. Body mass index and ovulatory infertility. Epidemiology. 1994;5:247–50. CrossRef
- Gesink Law DC, Maclehose RF, Longnecker MP. Obesity and time to pregnancy. Hum Reprod. 2007;22:414–20. CrossRef
- Jensen TK, Scheike T, Keiding N, Schaumburg I, Grandjean P. Fecundability in relation to body mass and menstrual cycle patterns. Epidemiology. 1999;10:422–8. CrossRef
- Bolumar F, Olsen J, Rebagliato M, Saez-Lloret I, Bisanti L. Body mass index and delayed conception: a European Multicenter Study on Infertility and Subfecundity. Am J Epidemiol. 2000;151:1072–9.
- Maheshwari A, Stofberg L, Bhattacharya S. Effect of overweight and obesity on assisted reproductive technology—a systematic review. Hum Reprod Update. 2007;13:433–44. CrossRef
- Sneed ML, Uhler ML, Grotjan HE, Rapisarda JJ, Lederer KJ, Beltsos AN. Body mass index: impact on IVF success appears age-related. Hum Reprod. 2008;23:1835–9. CrossRef
- Jain A, Polotsky AJ, Rochester D, Berga SL, Loucks T, Zeitlian G, et al. Pulsatile luteinizing hormone amplitude and progesterone metabolite excretion are reduced in obese women. J Clin Endocrinol Metab. 2007;92:2468–73. CrossRef
- Schneider G, Kirschner MA, Berkowitz R, Ertel NH. Increased estrogen production in obese men. J Clin Endocrinol Metab. 1979;48:633–8. CrossRef
- Giagulli VA, Kaufman JM, Vermeulen A. Pathogenesis of the decreased androgen levels in obese men. J Clin Endocrinol Metab. 1994;79:997–1000. CrossRef
- Clark AM, Thornley B, Tomlinson L, Galletley C, Norman RJ. Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Hum Reprod. 1998;13:1502–5. CrossRef
- Marceau P, Kaufman D, Biron S, Hould FS, Lebel S, Marceau S, et al. Outcome of pregnancies after biliopancreatic diversion. Obes Surg. 2004;14:318–24. CrossRef
- Rochester D, Jain A, Polotsky AJ, Polotsky H, Gibbs K, Isaac B, et al. Partial recovery of luteal function after bariatric surgery in obese women. Fertil Steril. 2009;92:1410–5. CrossRef
- Krishnamoorthy U, Schram CM, Hill SR. Maternal obesity in pregnancy: Is it time for meaningful research to inform preventive and management strategies? Bjog. 2006;113:1134–40.
- Smajdor A. Should IVF guidelines be relaxed in the UK? Expert Rev Obstet & Gynecol. 2009;4:501–8.
- di Frega AS, Dale B, Di Matteo L, Wilding M. Secondary male factor infertility after Roux-en-Y gastric bypass for morbid obesity: case report. Hum Reprod. 2005;20:997–8. CrossRef
- Globerman H, Shen-Orr Z, Karnieli E, Aloni Y, Charuzi I. Inhibin B in men with severe obesity and after weight reduction following gastroplasty. Endocr Res. 2005;31:17–26. CrossRef
- Bastounis EA, Karayiannakis AJ, Syrigos K, Zbar A, Makri GG, Alexiou D. Sex hormone changes in morbidly obese patients after vertical banded gastroplasty. Eur Surg Res. 1998;30:43–7. CrossRef
- Betz NE, Mintz L, Speakmon G. Gender differences in the accuracy of self-reported weight. Sex Roles. 1994;30:543–52. CrossRef
- Overweight Men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles
Journal of Assisted Reproduction and Genetics
Volume 27, Issue 9-10 , pp 539-544
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Male obesity
- In vitro fertilization
- IVF/ICSI outcome
- Assisted reproduction
- Industry Sectors
- Author Affiliations
- 1. Department of Obstetrics and Gynecology and Women’s Health, Albert Einstein College of Medicine, 1300 Morris Park Ave, Mazer Bldg, Room 322, Bronx, NY, USA
- 2. Montefiore’s Institute for Reproductive Medicine and Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA
- 3. Department of Obstetrics and Gynecology, University of Colorado, Denver, CO, 10461, USA