Journal of Assisted Reproduction and Genetics

, Volume 27, Issue 1, pp 3–12

Sperm DNA damage in male infertility: etiologies, assays, and outcomes

  • Ryan T. Schulte
  • Dana A. Ohl
  • Mark Sigman
  • Gary D. Smith
ANDROLOGY

DOI: 10.1007/s10815-009-9359-x

Cite this article as:
Schulte, R.T., Ohl, D.A., Sigman, M. et al. J Assist Reprod Genet (2010) 27: 3. doi:10.1007/s10815-009-9359-x

Abstract

Male factor infertility is the sole cause of infertility in approximately 20% of infertile couples, with an additional 30% to 40% secondary to both male and female factors. Current means of evaluation of male factor infertility remains routine semen analysis including seminal volume, pH, sperm concentration, motility, and morphology. However, approximately 15% of patients with male factor infertility have a normal semen analysis and a definitive diagnosis of male infertility often cannot be made as a result of routine semen analysis. Attention has focused on the role of sperm nuclear DNA integrity in male factor infertility. Here we review the structure of human sperm chromatin, the etiology and mechanisms of sperm DNA damage, current tests available to assess sperm DNA integrity, and effect of sperm DNA integrity on reproductive outcomes.

Keywords

EtiologiesAssaysSperm, DNA Damage

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Ryan T. Schulte
    • 1
  • Dana A. Ohl
    • 1
  • Mark Sigman
    • 2
  • Gary D. Smith
    • 1
    • 3
    • 4
    • 5
    • 6
  1. 1.Department of UrologyUniversity of MichiganAnn ArborUSA
  2. 2.Department of UrologyBrown Medical SchoolProvidenceUSA
  3. 3.Department of Obstetrics and GynecologyUniversity of MichiganAnn ArborUSA
  4. 4.Department of Integrated and Molecular PhysiologyUniversity of MichiganAnn ArborUSA
  5. 5.Department of Reproductive Sciences ProgramUniversity of MichiganAnn ArborUSA
  6. 6.Ann ArborUSA