Journal of Assisted Reproduction and Genetics

, Volume 26, Issue 1, pp 19–24

Comparison of letrozole with continuous gonadotropins and clomiphene-gonadotropin combination for ovulation induction in 1387 PCOS women after clomiphene citrate failure: a randomized prospective clinical trial

  • Ashalatha Ganesh
  • Sourendra Kant Goswami
  • Ratna Chattopadhyay
  • Koel Chaudhury
  • Baidyanath Chakravarty
GENERAL INFERTILITY

DOI: 10.1007/s10815-008-9284-4

Cite this article as:
Ganesh, A., Goswami, S.K., Chattopadhyay, R. et al. J Assist Reprod Genet (2009) 26: 19. doi:10.1007/s10815-008-9284-4

Abstract

Purpose

Letrozole, though reported to be an effective ovulation inducing agent, warrants larger randomized trials. The purpose of this study is to compare the efficacy of letrozole with that of rFSH and clomiphene citrate(CC)/rFSH for ovarian stimulation in IUI cycles.

Methods

Randomized, prospective, single-blinded clinical trial. 1387 PCOS women after CC failure were randomized into three groups: Group A received letrozole, Group B received CC with two doses rFSH and Group C received continuous rFSH day 2 onwards until hCG injection.

Results

Group A, B and C had an ovulation rate of 79.30%, 56.95% and 89.89% and cycle cancellation rate of 20.70%, 43.05% and 10.11%, respectively. Pregnancy rates in Group A, B and C were 23.39%, 14.35% and 17.92%, while the miscarriage rates were 13.80%, 16.67% and 14.52%, respectively.

Conclusion

Letrozole appears to be a suitable ovulation inducing agent in PCOS women with CC failure and is found to be most effective when baseline estradiol level >60 pg/ml.

Keywords

Baseline estradiolClomiphene citrate failureLetrozoleOvulation inductionrFSH

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Ashalatha Ganesh
    • 1
  • Sourendra Kant Goswami
    • 2
  • Ratna Chattopadhyay
    • 2
  • Koel Chaudhury
    • 1
  • Baidyanath Chakravarty
    • 2
  1. 1.School of Medical Science and TechnologyIndian Institute of TechnologyKharagpurIndia
  2. 2.Institute of Reproductive MedicineKolkataIndia