Assisted Reproduction

Journal of Assisted Reproduction and Genetics

, Volume 23, Issue 4, pp 177-184

FSH receptor gene polymorphisms have a role for different ovarian response to stimulation in patients entering IVF/ICSI-ET programs

  • Dimitris LoutradisAffiliated withDivision of Human Reproduction, IVF Unit, 1st Department of Obstetrics and Gynaecology, Athens University Medical School
  • , Eleni PatsoulaAffiliated withDivision of Human Reproduction, IVF Unit, 1st Department of Obstetrics and Gynaecology, Athens University Medical School
  • , Vassilis MinasAffiliated withLaboratory of Human Reproduction, Department of Obstetrics and Gynaecology, Medical School, University of Crete
  • , Giorgos A. KoussidisAffiliated withDivision of Human Reproduction, IVF Unit, 1st Department of Obstetrics and Gynaecology, Athens University Medical School
  • , Aristeidis AntsaklisAffiliated withDivision of Human Reproduction, IVF Unit, 1st Department of Obstetrics and Gynaecology, Athens University Medical School
  • , Stylianos MichalasAffiliated withDivision of Human Reproduction, IVF Unit, 1st Department of Obstetrics and Gynaecology, Athens University Medical School
  • , Antonis MakrigiannakisAffiliated withLaboratory of Human Reproduction, Department of Obstetrics and Gynaecology, Medical School, University of Crete Email author 

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Purpose: To examine the frequency distribution of the Ser680Asn polymorphism of the follicle-stimulating hormone receptor (FSHR) gene in ovarian dysfunction (OD) infertile women, “poor responders” (PR) and “good responders” (GR).

Methods: The hormonal profiles and treatment of all patients were analyzed and FSHR polymorphism was examined by PCR and RFLP. Women from all groups were classified as Asn/Asn, Asn/Ser, and Ser/Ser genotypes.

Results: The frequency distribution of Ser/Ser, Asn/Ser and Asn/Asn variants in OD patients was 45.5, 22.7, and 31.8%, respectively. Day 3 FSH levels in OD and GR patients were higher in Ser/Ser and Asn/Asn subgroups. Asn/Ser carriers from OD and GR groups provided more follicles and oocytes compared to other allelic variants.

Conclusions: GR patients carry more often the Asn/Ser genotype. The latter is correlated with more follicles and oocytes in both OD and GR patients. The Ser/Ser variant might be related to higher serum FSH levels, while the Asn/Ser with lower.

KEY WORDS :

FSH receptor gene polymorphisms ovarian response ovarian stimulation.