Journal of Autism and Developmental Disorders

, Volume 44, Issue 10, pp 2547–2557

Epilepsy Among Children and Adolescents with Autism Spectrum Disorders: A Population-Based Study

Authors

    • Department of Child PsychiatryUniversity of Turku
    • Turku University Hospital
  • Andre Sourander
    • Department of Child PsychiatryUniversity of Turku
    • Turku University Hospital
    • Department of Psychiatry, New York State Psychiatric InstituteColumbia University College of Physicians and Surgeons
  • Auli Suominen
    • Department of Child PsychiatryUniversity of Turku
    • Turku University Hospital
  • Laura Timonen-Soivio
    • Department of Child PsychiatryUniversity of Turku
    • Turku University Hospital
    • Department of Child NeurologyHelsinki University Central Hospital
  • Alan S. Brown
    • Department of Psychiatry, New York State Psychiatric InstituteColumbia University College of Physicians and Surgeons
    • Department of Epidemiology, Mailman School of Public HealthColumbia University
  • Matti Sillanpää
    • Department of Child NeurologyUniversity of Turku
    • Department of Public HealthUniversity of Turku
Original Paper

DOI: 10.1007/s10803-014-2126-6

Cite this article as:
Jokiranta, E., Sourander, A., Suominen, A. et al. J Autism Dev Disord (2014) 44: 2547. doi:10.1007/s10803-014-2126-6

Abstract

The present population-based study examines associations between epilepsy and autism spectrum disorders (ASD). The cohort includes register data of 4,705 children born between 1987 and 2005 and diagnosed as cases of childhood autism, Asperger’s syndrome or pervasive developmental disorders—not otherwise specified. Each case was matched to four controls by gender, date of birth, place of birth, and residence in Finland. Epilepsy was associated with ASD regardless of the subgroup after adjusting for covariates. The associations were stronger among cases with intellectual disability, especially among females. Epilepsy’s age at onset was similar between the cases and controls regardless of the ASD subgroup. These findings emphasize the importance to examine the neurodevelopmental pathways in ASD, epilepsy and intellectual disability.

Keywords

EpilepsyAutism spectrum disordersIntellectual disabilityGenderAge at onsetPopulation-based

Abbreviations

ASD

Autism spectrum disorder

CPR

Finnish Central Population Register

FIPS-A

Finnish Prenatal Study of Autism and Autism Spectrum Disorders

FHDR

Finnish Hospital Discharge Register

FMBR

Finnish Medical Birth Register

ICD

International Classification of Diseases

ID

Intellectual disability

PDD-NOS

Pervasive developmental disorder—not otherwise specified

SE

Status epilepticus

THL

National Institute for Health and Welfare

Copyright information

© Springer Science+Business Media New York 2014