Journal of Autism and Developmental Disorders

, Volume 44, Issue 10, pp 2602–2607

Brief Report: Are Autistic-Behaviors in Children Related to Prenatal Vitamin Use and Maternal Whole Blood Folate Concentrations?

  • Joseph M. Braun
  • Tanya Froehlich
  • Amy Kalkbrenner
  • Christine M. Pfeiffer
  • Zia Fazili
  • Kimberly Yolton
  • Bruce P. Lanphear
Brief Report

DOI: 10.1007/s10803-014-2114-x

Cite this article as:
Braun, J.M., Froehlich, T., Kalkbrenner, A. et al. J Autism Dev Disord (2014) 44: 2602. doi:10.1007/s10803-014-2114-x

Abstract

Prenatal multivitamin/folic acid supplement use may reduce the risk of autism spectrum disorders. We investigated whether 2nd trimester prenatal vitamin use and maternal whole blood folate (WBF) concentrations were associated with Social Responsiveness Scale (SRS) scores at 4–5 years of age in a prospective cohort of 209 mother–child pairs. After confounder adjustment, children born to women taking prenatal vitamins weekly/daily (n = 179) had lower odds of clinically elevated SRS scores (odds ratio 0.26; 95 % confidence interval 0.08, 0.89) than those who rarely/never took them (n = 30). WBF concentrations were not associated with SRS scores. The lack of association between WBF and autistic-behaviors may be due to the timing of biomarker measures relative to critical periods of brain development, confounding, or other modifying factors.

Keywords

Autism spectrum disordersFolatePregnancyPrenatal vitamins

Abbreviations

ASDs

Autism spectrum disorders

CDC

Centers for Disease Control and Prevention

CI

95 % Confidence interval

OR

Odds ratio

SD

Standard deviation

SRS

Social Responsiveness Scale

WBF

Whole blood folate

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Joseph M. Braun
    • 1
  • Tanya Froehlich
    • 2
  • Amy Kalkbrenner
    • 3
  • Christine M. Pfeiffer
    • 4
  • Zia Fazili
    • 4
  • Kimberly Yolton
    • 2
  • Bruce P. Lanphear
    • 5
    • 6
  1. 1.Department of EpidemiologyBrown University School of Public Health, Brown UniversityProvidenceUSA
  2. 2.Department of PediatricsCincinnati Children’s Hospital Medical CenterCincinnatiUSA
  3. 3.Zilber School of Public HealthUniversity of Wisconsin-MilwaukeeMilwaukeeUSA
  4. 4.Division of Laboratory Sciences, Centers for Disease Control and PreventionNational Center for Environmental HealthAtlantaUSA
  5. 5.Faculty of Health and SciencesSimon Fraser UniversityBurnabyCanada
  6. 6.Child and Family Research InstituteBC Children’s and Women’s HospitalVancouverCanada