Brief Report: Are Autistic-Behaviors in Children Related to Prenatal Vitamin Use and Maternal Whole Blood Folate Concentrations?
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Prenatal multivitamin/folic acid supplement use may reduce the risk of autism spectrum disorders. We investigated whether 2nd trimester prenatal vitamin use and maternal whole blood folate (WBF) concentrations were associated with Social Responsiveness Scale (SRS) scores at 4–5 years of age in a prospective cohort of 209 mother–child pairs. After confounder adjustment, children born to women taking prenatal vitamins weekly/daily (n = 179) had lower odds of clinically elevated SRS scores (odds ratio 0.26; 95 % confidence interval 0.08, 0.89) than those who rarely/never took them (n = 30). WBF concentrations were not associated with SRS scores. The lack of association between WBF and autistic-behaviors may be due to the timing of biomarker measures relative to critical periods of brain development, confounding, or other modifying factors.
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- Brief Report: Are Autistic-Behaviors in Children Related to Prenatal Vitamin Use and Maternal Whole Blood Folate Concentrations?
Journal of Autism and Developmental Disorders
Volume 44, Issue 10 , pp 2602-2607
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
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- Autism spectrum disorders
- Prenatal vitamins
- Industry Sectors
- Author Affiliations
- 1. Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, RI, 02912, USA
- 2. Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 45229, USA
- 3. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, 53201, USA
- 4. Division of Laboratory Sciences, Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, GA, 30341, USA
- 5. Faculty of Health and Sciences, Simon Fraser University, Burnaby, V5A 1S6, Canada
- 6. Child and Family Research Institute, BC Children’s and Women’s Hospital, Vancouver, V5Z 4H48, Canada