Journal of Autism and Developmental Disorders

, Volume 43, Issue 11, pp 2526–2535

Parental Age and Risk of Autism Spectrum Disorders in a Finnish National Birth Cohort

  • Katja M. Lampi
  • Susanna Hinkka-Yli-Salomäki
  • Venla Lehti
  • Hans Helenius
  • Mika Gissler
  • Alan S. Brown
  • Andre Sourander
Original Paper

DOI: 10.1007/s10803-013-1801-3

Cite this article as:
Lampi, K.M., Hinkka-Yli-Salomäki, S., Lehti, V. et al. J Autism Dev Disord (2013) 43: 2526. doi:10.1007/s10803-013-1801-3

Abstract

Aim of the study was to examine the associations between parental age and autism spectrum disorders (ASD). Data were based on the FIPS-A (Finnish Prenatal Study of Autism and Autism Spectrum Disorders), a case-control study with a total of 4,713 cases with childhood autism (n = 1,132), Asperger’s syndrome (n = 1,785) or other pervasive developmental disorder (PDD) (n = 1,796), which were ascertained from the Finnish Hospital Discharge Register. Controls were selected from the Finnish Medical Birth Register. Conditional logistic regression models were used for statistical analyses. Advanced paternal age (35–49 years) was associated with childhood autism in offspring, whereas advanced maternal age was associated with both Asperger’s syndrome and PDD in offspring (35 years or more and 40 years or more, respectively). Teenage motherhood (19 years or less) was associated with PDD in offspring. The main finding was that maternal and paternal ages were differentially associated with ASD subtypes. In addition to advanced parental age, teenage pregnancy seems to incur a risk for PDD in offspring.

Keywords

Epidemiology Autism spectrum disorders Parental age 

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Katja M. Lampi
    • 1
  • Susanna Hinkka-Yli-Salomäki
    • 1
  • Venla Lehti
    • 1
  • Hans Helenius
    • 2
  • Mika Gissler
    • 1
    • 3
    • 4
  • Alan S. Brown
    • 5
    • 6
  • Andre Sourander
    • 1
    • 7
  1. 1.Department of Child PsychiatryUniversity of TurkuTurkuFinland
  2. 2.Department of BiostatisticsUniversity of TurkuTurkuFinland
  3. 3.National Institute of Health and Welfare (THL)HelsinkiFinland
  4. 4.Nordic School of Public HealthGothenburgSweden
  5. 5.Department of Psychiatry, College of Physicians and Surgeons of Columbia UniversityNew York State Psychiatric InstituteNew YorkUSA
  6. 6.Department of Epidemiology, Mailman School of Public HealthColumbia UniversityNew YorkUSA
  7. 7.Department of Child PsychiatryTurku University HospitalTurkuFinland