Journal of Autism and Developmental Disorders

, Volume 43, Issue 8, pp 1749–1757

Changing Concepts and Findings on Autism


    • MRC Social Genetic and Developmental Psychiatry Centre (SGDP), Institute of PsychiatryKing’s College London
Original Paper

DOI: 10.1007/s10803-012-1713-7

Cite this article as:
Rutter, M. J Autism Dev Disord (2013) 43: 1749. doi:10.1007/s10803-012-1713-7


New research findings provide major challenges regarding our understanding of the concept of autism. These are critically discussed in relation to research relevant to classification, genetics, environmental risk factors, gene-environment interplay, animal models, biomarkers, clinical features, neuropathology, pharmacotherapy, behavioral treatments, and functioning in adult life. It is concluded that, although there have been major research advances; there is a need for a reconceptualization and an avoidance of claims that go beyond the evidence.


Phenotypic overlap among disorders Genetic overlap Fractionable autism triad Broader autism phenotype Rett syndrome Epilepsy

Copyright information

© Springer Science+Business Media New York 2012