Original Paper

Journal of Autism and Developmental Disorders

, Volume 43, Issue 7, pp 1630-1641

The Relationship Between Grey-Matter and ASD and ADHD Traits in Typical Adults

  • Hilde M. GeurtsAffiliated withBrain and Cognition, Department of Psychology, Universiteit van AmsterdamDepartment of Psychology, ADHD and Autism Research Center (d’Arc), Universiteit van Amsterdam Email author 
  • , K. Richard RidderinkhofAffiliated withBrain and Cognition, Department of Psychology, Universiteit van AmsterdamDepartment of Psychology, Amsterdam Center for the Study of Adaptive Control in Brain and Behavior (Acacia), Universiteit van AmsterdamCognitive Science Centre Amsterdam (CSCA), Universiteit van Amsterdam
  • , H. Steven ScholteAffiliated withBrain and Cognition, Department of Psychology, Universiteit van Amsterdam

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Abstract

We tested whether in 85 healthy adults (18–29 years) there is a relationship between grey-matter (GM) volume and autism and ADHD symptom severity. The structural MRI findings and autism and ADHD self-reports revealed that autism and ADHD symptom severity was correlated with GM volume in the left inferior frontal gyrus. Autism symptom-severity was correlated with the left posterior cingulate, ADHD with the right parietal lobe, right temporal frontal cortex, bilateral thalamus, and left hippocampus/amygdala complex. Symptom severity of both disorders form a continuum extending into the general population, but it seems to be an oversimplification to typify psychiatric disorders such as autism and ADHD solely as extremes of brain structure abnormalities.

Keywords

ADHD Autism ASD VBM Grey-matter sMRI