Is Infertility Associated with Childhood Autism?
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Concerns persist about a possible link between infertility and risk of autism spectrum disorders (ASD). Interpretation of existing studies is limited by racial/ethnic homogeneity of study populations and other factors. Using a case–control design, we evaluated infertility history and treatment documented in medical records of members of Kaiser Permanente Northern California. Among singletons (349 cases, 1,847 controls), we found no evidence to support an increase in risk of ASD associated with infertility. Among multiple births (21 cases, 54 controls), we found an increased risk associated with infertility history and with infertility evaluations and treatment around the time of index pregnancy conception; however, small sample size and lack of detailed data on treatments preclude firm interpretation of results for multiple births.
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- Is Infertility Associated with Childhood Autism?
Journal of Autism and Developmental Disorders
Volume 43, Issue 3 , pp 663-672
- Cover Date
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- Springer US
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- Infertility treatments
- Multiple births
- Industry Sectors
- Author Affiliations
- 1. California Department of Public Health, Environmental Health Investigations Branch, Richmond, CA, 94804, USA
- 2. Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, 2000 Broadway, Oakland, CA, 94612, USA
- 3. Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, CA, 94143, USA
- 4. Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, 94143, USA
- 5. Department of Neurology, University of California, San Francisco, CA, 94143, USA
- 6. Department of Pediatrics, University of California, San Francisco, CA, 94143, USA
- 7. School of Nursing, Samuel Merritt University, San Mateo, CA, 94402, USA