Journal of Autism and Developmental Disorders

, Volume 43, Issue 1, pp 25–33

Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study

  • Ousseny Zerbo
  • Ana-Maria Iosif
  • Cheryl Walker
  • Sally Ozonoff
  • Robin L. Hansen
  • Irva Hertz-Picciotto
Original Paper

DOI: 10.1007/s10803-012-1540-x

Cite this article as:
Zerbo, O., Iosif, AM., Walker, C. et al. J Autism Dev Disord (2013) 43: 25. doi:10.1007/s10803-012-1540-x

Abstract

We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR’s (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99).

Keywords

Maternal influenzaFeverAutismAnti-fever medication

Supplementary material

10803_2012_1540_MOESM1_ESM.doc (44 kb)
Supplementary material 1 (DOC 44 kb)

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Ousseny Zerbo
    • 1
    • 4
  • Ana-Maria Iosif
    • 1
  • Cheryl Walker
    • 1
  • Sally Ozonoff
    • 2
  • Robin L. Hansen
    • 2
    • 3
  • Irva Hertz-Picciotto
    • 1
    • 2
  1. 1.Department of Public Health Sciences, MS1CUniversity of CaliforniaDavisUSA
  2. 2.The UC Davis Medical Investigation of Neurodevelopmental Disorders (MIND) InstituteSacramentoUSA
  3. 3.Department of PediatricsUniversity of CaliforniaDavisUSA
  4. 4.Division of ResearchKaiser PermanenteOaklandUSA