Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes
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Supplemental melatonin has shown promise in treating sleep onset insomnia in children with autism spectrum disorders (ASD). Twenty-four children, free of psychotropic medications, completed an open-label dose-escalation study to assess dose–response, tolerability, safety, feasibility of collecting actigraphy data, and ability of outcome measures to detect change during a 14-week intervention. Supplemental melatonin improved sleep latency, as measured by actigraphy, in most children at 1 or 3 mg dosages. It was effective in week 1 of treatment, maintained effects over several months, was well tolerated and safe, and showed improvement in sleep, behavior, and parenting stress. Our findings contribute to the growing literature on supplemental melatonin for insomnia in ASD and inform planning for a large randomized trial in this population.
- Abidin, R. R. (1995). Parenting stress index (3rd ed.). Odessa, FL: Psychological Assessment Resources.
- Achenbach, T. M., & Rescorla, L. A. (2001a). Manual for the ASEBA preschool forms and profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth, and Families.
- Achenbach, T. M., & Rescorla, L. A. (2001b). Manual for the ASEBA school age forms and profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth, and Families.
- Adkins, K. W., Goldman, S.E., Fawkes, D., Surdyka, K., Wang, L., & Song, Y. et al. (in press). A pilot study of shoulder placement for actigraphy in children. Behavioral Sleep Medicine.
- American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders, 4th edn, Text Revision. Washington DC: American Psychiatric Association.
- Andersen, I. M., Kaczmarska, J., McGrew, S. G., & Malow, B. A. (2008). Melatonin for insomnia in children with autism spectrum disorders. Journal of Child Neurology, 23(5), 482–485. CrossRef
- Bodfish, J. W., Symons, F. J., Parker, D. E., & Lewis, M. H. (2000). Varieties of repetitive behavior in autism: Comparisons to mental retardation. Journal of Autism and Developmental Disorders, 30(3), 237–243. CrossRef
- Carpay, J. A., Arts, W. F. M., Vermeulen, J., Stroink, H., Brouwer, O. F., Peters, A. C. B., et al. (1996). Parent-completed scales for measuring seizure severity and severity of side-effects on antiepileptic drugs in childhood epilepsy: Development and psychometric analysis. Epilepsy Research, 24, 173–181. CrossRef
- Chervin, R. D., Ruzicka, D. L., Giordani, B. J., et al. (2006). Sleep-disordered breathing, behavior, and cognition in children before and after adenotonsillectomy. Pediatrics, 117, 769–778. CrossRef
- Couturier, J. L., Speechley, K. N., Steele, M., Norman, R., Stringer, B., Nicholson, R., et al. (2005). Parental perception of sleep problems in children of normal intelligence with pervasive developmental disorders: Prevalence, severity, and pattern. Journal of the American Academy of Child and Adolescent Psychiatry, 44, 815–822. CrossRef
- Doyen, C., Mighiu, D., Kaye, K., Colineaux, C., Beaumanior, C., Mauraeff, Y., et al. (2011). Melatonin in children with autistic spectrum disorders: Recent and practical data. European Child and Adolescent Psychiatry, 20, 231–239. CrossRef
- Dunn, L. M. (1997). Peabody picture vocabulary test (3rd ed.). Minneapolis, MN: American Guidance Service.
- Gabriels, R. L., Cuccaro, M. L., Hill, D. E., Ivers, B. J., & Goldson, E. (2005). Repetitive behaviors in autism: Relationships with associated clinical features. Research on Developmental Disabilities, 26, 169–181. CrossRef
- Goldman, S. E., Mc Grew, S., Johnson, K. P., Richdale, A. L., Clemons, T., & Malow, B. A. (2011a). Sleep is associated with problem behaviors in children and adolescents with autism spectrum disorders. Research in Autism Spectrum Disorders, 5, 1223–1229. CrossRef
- Goldman S. E., Richdale A. L., Clemons T., & Malow B. A. (2011b). Sleep behaviors in autism spectrum disorders—variations in age from early childhood through adolescence. Journal of Autism and Developmental Disorders, May 3 (epub ahead of print).
- Goldman, S. E., Surdyka, K., Cuevas, R., Adkins, K., Wang, L., Malow, B. A., et al. (2009). Defining the sleep phenotype in children with autism. Developmental Neuropsychology, 34, 560–573. CrossRef
- Goodlin-Jones, B. L., Sitnick, S. L., & Tang, K. (2008). The children’s sleep habits questionnaire in toddlers and preschool children. Journal of Developmental and Behavioral Pediatrics, 29, 82–88. CrossRef
- Guénolé, F., Godbout, R., Nicolas, A., Franco, P., Claustrat, B., & Baleyte, J. M. (2011). Melatonin for disordered sleep in individuals with autism spectrum disorders: Systematic review and discussion. Sleep Medicine Reviews, 15(6), 379–387. CrossRef
- Harrington, J. W., Rosen, L., & Garnecho, A. (2006). Parental perceptions and use of complementary and alternative medicine practices for children with autism spectrum disorders in private practice. Journal of Developmental and Behavioral Pediatrics, 27(2 Suppl), S156–S161. CrossRef
- Hollingshead, A. B. (1975). Four factor index of social status. New Haven, CT: Yale University, Department of Sociology.
- Hollway, J. A., & Aman, M. G. (2011). Sleep correlates of pervasive developmental disorders: A review of the literature. Research in Developmental Disabilities. doi:10.1016/j.ridd.2011.04.001.
- Kaufman, A. S., & Kaufman, N. L. (2004). Kaufman brief intelligence test (2nd ed.). Circle Press, MN: American Guidance Service, Inc.
- Krakowiak, P., Goodlin-Jones, B., Hertz-Picciotto, I., Croen, L. A., & Hansen, R. L. (2008). Sleep problems in children with autism spectrum disorders, developmental delays, and typical development: A population-based study. Journal of Sleep Research, 17, 197–206. CrossRef
- Kushida, C. A., Chang, A., Gadkary, C., Guilleminault, C., Carrillo, O., Dement, W. C., et al. (2001). Comparison of actigraphic, polysomnographic, and subjective assessment of sleep parameters in sleep-disordered patients. Sleep Medicine, 2, 389–396. CrossRef
- Lam, K. S. L., & Aman, M. G. (2007). The repetitive behavior scale-revised: Independent validation in individuals with autism spectrum disorders. Journal of Autism Developmental Disorders, 37(5), 855–866. CrossRef
- Lichstein, K. L., Stone, K. C., Donaldson, J., Nau, S. D., Soeffing, J. P., Murray, D., et al. (2006). Actigraphy validation with insomnia. Sleep, 29, 232–239.
- Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Jr, Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism Developmental Disorders, 30(3), 205–223. CrossRef
- Malow, B. A., Marzec, M. L., McGrew, S. G., Wang, L., & Stone, W. (2006). Characterizing sleep in children with autism spectrum disorders: A multidimensional approach. Sleep, 29, 1563–1571.
- Mayes, S. D., & Calhoun, S. (2009). Variables related to sleep problems in children with autism. Research in Autism Spectrum Disorder, 3, 931–941. CrossRef
- Mezick, E. J., Matthews, K. A., Hall, M., Kamarck, T. W., Buysse, D. J., Owens, J. F., et al. (2009). Intra-individual variability in sleep duration and fragmentation: Associations with stress. Psychoneuroendocrinology, 34, 1346–1354. CrossRef
- Mirenda, R., Smith, I. M., & Vaillancourt, T. (2010). Validating the repetitive behavior scale-revised in young children with autism spectrum disorder. Journal of Autism Developmental Disorders, 40, 1521–1530. CrossRef
- Owens, J. A., Spirito, A., & McGuinn, M. (2000). The children’s sleep habits questionnaire (CSHQ): Psychometric properties of a survey instrument for school-aged children. Sleep, 23, 1043–1051.
- Phillips Respironics. Actiware/Actiware-ct (2010). Actiwatch communication and sleep analysis software instruction manual. Software Version 5.9.
- Reed, H. E., McGrew, S. G., Artibee, K., Surdyka, K., Goldman, S. E., & Frank, K. (2009). Parent-based sleep education workshops in autism. Journal of Child Neurology, 24, 236–245. CrossRef
- Richdale, A. L., & Schreck, K. A. (2009). Sleep problems in autism spectrum disorders: Prevalence, nature, & possible biopsychosocial aetiologies. Sleep Medicine Reviews, 13(6), 403–411. CrossRef
- Rossignol, D., & Frye, R. (2011). Melatonin in autism spectrum disorders: A systemic review and meta-analysis. Developmental Medicine and Child Neurology, 53(9), 783–792. CrossRef
- Schreck, K. A., Mulick, J. A., & Smith, A. F. (2004). Sleep problems as possible predictors of intensified symptoms of autism. Research Developmental Disabilities, 25, 57–66. CrossRef
- Souders, M. C., Mason, T. B., Valladares, O., Bucan, M., Levy, S. A., Mandell, D. S., et al. (2009). Sleep behaviors and sleep quality in children with autism spectrum disorders. Sleep, 32, 1566–1578.
- Westfall, P., Tobias, R. D., Ron, D., Wolfinger, R. D., & Hochberg, Y. (1999). Multiple comparisons and multiple tests using SAS. Cary, NC: SAS Institute Inc.
- Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes
Journal of Autism and Developmental Disorders
Volume 42, Issue 8 , pp 1729-1737
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Clinical trial
- Children’s sleep habits questionnaire
- Child behavior checklist
- Autism diagnostic observation schedule
- Industry Sectors
- Author Affiliations
- 1. Sleep Disorders Division, Department of Neurology and Kennedy Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, Room Room A-0116, Nashville, TN, 37232, USA
- 2. Sleep Disorders Division, Department of Neurology, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA
- 3. Department of Pediatrics, Monroe Carell Children’s Hospital at Vanderbilt, Nashville, TN, 37232, USA
- 4. Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA