Original Paper

Journal of Autism and Developmental Disorders

, Volume 42, Issue 8, pp 1662-1670

Normal Rates of Neuroradiological Findings in Children with High Functioning Autism

  • Roma A. VasaAffiliated withLaboratory of Neurocognitive and Imaging Research, Center for Autism and Related Disorders, Kennedy Krieger Institute, Johns Hopkins University School of Medicine Email author 
  • , Marin RantaAffiliated withKennedy Krieger Institute
  • , Thierry A. G. M. HuismanAffiliated withDivision of Pediatric Radiology, Department of Radiology and Radiological Science, Johns Hopkins Hospital, Johns Hopkins University School of Medicine
  • , Pedro S. PintoAffiliated withDivision of Pediatric Radiology, Department of Radiology and Radiological Science, Johns Hopkins Hospital
  • , Rachael M. TillmanAffiliated withKennedy Krieger Institute
  • , Stewart H. MostofskyAffiliated withLaboratory of Neurocognitive and Imaging Research, Center for Autism and Related Disorders, Kennedy Krieger Institute, Johns Hopkins University School of Medicine

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Abstract

Magnetic resonance imaging (MRI) has been used to analyze highly specific volumetric and morphological features of the brains of individuals with autism spectrum disorder (ASD). To date, there are few comprehensive studies examining the prevalence of neuroradiologic findings seen on routine MRI scans in children with ASD. This study examined the prevalence of neuroradiologic findings in children with high functioning ASD, and compared these rates to those in children with Attention-Deficit/Hyperactivity Disorder (ADHD) and children who are typically developing (TD). Results showed that approximately 90% of children had normal MRI scans. There was no significant effect of diagnosis on the total number of neuroradiological findings or the number of specific brain findings. Implications and future research directions are discussed.

Keywords

Autism Magnetic resonance imaging Neuroradiological findings