Letter to the Editor

Journal of Autism and Developmental Disorders

, Volume 42, Issue 4, pp 643-646

Further Commentary on Mitochondrial Dysfunction in Autism Spectrum Disorder: Assessment and Treatment Considerations

  • Stephen R. DagerAffiliated withDepartment of Radiology, University of WashingtonUniversity of Washington Autism CenterDepartment of Bioengineering, University of Washington Email author 
  • , Neva M. CorriganAffiliated withDepartment of Radiology, University of Washington
  • , Annette EstesAffiliated withUniversity of Washington Autism CenterDepartment of Speech and Hearing Sciences, University of Washington
  • , Dennis W. W. ShawAffiliated withDepartment of Radiology, University of WashingtonSeattle Children’s Hospital

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Abstract

The authors respond to a recent letter (Rossignol and Frye 2011) critical of their paper, “Proton magnetic resonance spectroscopy and MRI reveal no evidence for brain mitochondrial dysfunction in children with autism spectrum disorder” (Corrigan et al. 2011). Further considerations regarding the assessment of mitochondrial dysfunction in autism spectrum disorder, and related treatment considerations, are discussed.

Keywords

Autism Developmental disorders MRS MRI Mitochondrial disorders Brain lactate