Journal of Autism and Developmental Disorders

, Volume 42, Issue 3, pp 432–440

Design and Subject Characteristics in the Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders

  • Lawrence Scahill
  • James T. McCracken
  • Karen Bearss
  • Fay Robinson
  • Eric Hollander
  • Bryan King
  • Joel Bregman
  • Lin Sikich
  • Kimberly Dukes
  • Lisa Sullivan
  • Evdokia Anagnostou
  • Craig Donnelly
  • Young-Shin Kim
  • Louise Ritz
  • Deborah Hirtz
  • Ann Wagner
original paper

DOI: 10.1007/s10803-011-1251-8

Cite this article as:
Scahill, L., McCracken, J.T., Bearss, K. et al. J Autism Dev Disord (2012) 42: 432. doi:10.1007/s10803-011-1251-8

Abstract

The Studies to Advance Autism Research and Treatment Network conducted a randomized trial with citalopram in children with Pervasive developmental disorders (PDDs). We present the rationale, design and sample characteristics of the citalopram trial. Subjects (128 boys, 21 girls) had a mean age of 9.3 (±3.12) years; 132 (88.6%) were diagnosed with autistic disorder (4.7% with Asperger’s Disorder; 6.7% with PDD-not otherwise specified). Less than half of the subjects were intellectually disabled; 117 (78.5%) were rated Moderate or Marked on the Clinical Global Impression for Severity. Study measures were similar to previous Research Units on Pediatric Psychopharmacology trials. Subjects in this trial were slightly older and more likely to have complaints of repetitive behavior than participants in RUPP trials.

Keywords

AutismSerotonin reuptake inhibitorsCitalopramDouble-blind methodRepetitive behavior

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Lawrence Scahill
    • 1
  • James T. McCracken
    • 2
  • Karen Bearss
    • 1
  • Fay Robinson
    • 3
  • Eric Hollander
    • 4
    • 12
  • Bryan King
    • 5
    • 13
  • Joel Bregman
    • 6
    • 14
  • Lin Sikich
    • 7
  • Kimberly Dukes
    • 3
  • Lisa Sullivan
    • 8
  • Evdokia Anagnostou
    • 4
    • 15
  • Craig Donnelly
    • 5
  • Young-Shin Kim
    • 9
  • Louise Ritz
    • 10
    • 16
  • Deborah Hirtz
    • 11
  • Ann Wagner
    • 10
  1. 1.Yale University School of Nursing and Child Study CenterNew HavenUSA
  2. 2.University of CaliforniaLos AngelesUSA
  3. 3.DM STATBostonUSA
  4. 4.Mt. Sinai Medical SchoolNew YorkUSA
  5. 5.Dartmouth Medical SchoolHanoverUSA
  6. 6.North Shore Long Island Jewish Health SystemManhassetUSA
  7. 7.University of North CarolinaChapel HillUSA
  8. 8.Boston UniversityBostonUSA
  9. 9.Yale UniversityNew HavenUSA
  10. 10.National Institute of Mental HealthBethesdaUSA
  11. 11.National Institute of Neurological Disorders and StrokeBethesdaUSA
  12. 12.Albert Einstein College of Medicine and Montefiore Medical CenterNew YorkUSA
  13. 13.University of Washington & Seattle Children’s HospitalSeattleUSA
  14. 14.University of MissouriColumbiaUSA
  15. 15.Bloorview Research InstituteUniversity of TorontoTorontoCanada
  16. 16.National Institute of Neurological Disorders and StrokeBethesdaUSA