Journal of Autism and Developmental Disorders

, Volume 42, Issue 1, pp 105–115

Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder

  • Neva M. Corrigan
  • Dennis. W. W. Shaw
  • Todd L. Richards
  • Annette M. Estes
  • Seth D. Friedman
  • Helen Petropoulos
  • Alan A. Artru
  • Stephen R. Dager
Original Paper

DOI: 10.1007/s10803-011-1216-y

Cite this article as:
Corrigan, N.M., Shaw, D.W.W., Richards, T.L. et al. J Autism Dev Disord (2012) 42: 105. doi:10.1007/s10803-011-1216-y

Abstract

Brain mitochondrial dysfunction has been proposed as an etiologic factor in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopic imaging (1HMRS) and MRI were used to assess for evidence of brain mitochondrial dysfunction in longitudinal samples of children with ASD or developmental delay (DD), and cross-sectionally in typically developing (TD) children at 3–4, 6–7 and 9–10 years-of-age. A total of 239 studies from 130 unique participants (54ASD, 22DD, 54TD) were acquired. 1HMRS and MRI revealed no evidence for brain mitochondrial dysfunction in the children with ASD. Findings do not support a substantive role for brain mitochondrial abnormalities in the etiology or symptom expression of ASD, nor the widespread use of hyperbaric oxygen treatment that has been advocated on the basis of this proposed relationship.

Keywords

AutismDevelopmental disordersMRSMRIMitochondrial disordersBrain metabolismLactate

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Neva M. Corrigan
    • 1
  • Dennis. W. W. Shaw
    • 1
    • 2
  • Todd L. Richards
    • 1
  • Annette M. Estes
    • 4
    • 5
  • Seth D. Friedman
    • 2
  • Helen Petropoulos
    • 1
  • Alan A. Artru
    • 3
  • Stephen R. Dager
    • 1
    • 4
    • 6
  1. 1.Department of RadiologyUniversity of WashingtonSeattleUSA
  2. 2.Seattle Children’s HospitalSeattleUSA
  3. 3.Department of AnesthesiologyUniversity of WashingtonSeattleUSA
  4. 4.University of Washington Autism CenterSeattleUSA
  5. 5.Department of Speech and Hearing SciencesUniversity of WashingtonSeattleUSA
  6. 6.Department of BioengineeringUniversity of WashingtonSeattleUSA