Journal of Autism and Developmental Disorders

, Volume 41, Issue 12, pp 1665–1674

The Nature of Covariation Between Autistic Traits and Clumsiness: A Twin Study in a General Population Sample

  • Sara Moruzzi
  • Anna Ogliari
  • Angelica Ronald
  • Francesca Happé
  • Marco Battaglia
Original Paper

DOI: 10.1007/s10803-011-1199-8

Cite this article as:
Moruzzi, S., Ogliari, A., Ronald, A. et al. J Autism Dev Disord (2011) 41: 1665. doi:10.1007/s10803-011-1199-8

Abstract

While social impairment, difficulties with communication, and restricted repetitive behaviors are central features of Autism Spectrum Disorders, physical clumsiness is a commonly co-occuring feature. In a sample of 398 twin pairs (aged 8–17 years) from the Italian Twin Registry we investigated the nature of the co-variation between a psychometric index of Clumsiness and the Child Behavior Checklist (CBCL) Autistic scale. Bivariate twin analyses showed that a genetic etiological overlap, rather than direct causation, is a plausible explanation for the association between clumsiness and autistic-like traits, as measured by indices derived from the parent-rated CBCL scale. Additive genetic influences that impinge upon clumsiness/motor problem and autistic-like traits coincided remarkably, with a genetic correlation of 0.63.

Keywords

ClumsinessAutistic traitsCBCLComorbidityTwin study

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Sara Moruzzi
    • 1
  • Anna Ogliari
    • 1
    • 2
  • Angelica Ronald
    • 3
  • Francesca Happé
    • 4
  • Marco Battaglia
    • 1
    • 2
    • 5
  1. 1.The Academic Centre for the Study of Behavioural PlasticityVita-Salute San Raffaele UniversityMilanItaly
  2. 2.Istituto Scientifico San RaffaeleMilanItaly
  3. 3.Department of Psychological Sciences, Centre for Brain and Cognitive DevelopmentBirkbeck, University of LondonLondonUK
  4. 4.MRC Social, Genetic and Developmental Psychiatry Centre, Institute of PsychiatryKing’s College LondonLondonUK
  5. 5.The Department of Child PsychiatryIstituto Scientifico Eugenio MedeaBosisio PariniItaly