Journal of Autism and Developmental Disorders

, Volume 41, Issue 11, pp 1455–1463

Is Neonatal Jaundice Associated with Autism Spectrum Disorders: A Systematic Review

Original paper

DOI: 10.1007/s10803-010-1169-6

Cite this article as:
Amin, S.B., Smith, T. & Wang, H. J Autism Dev Disord (2011) 41: 1455. doi:10.1007/s10803-010-1169-6

Abstract

Using guidelines of the Meta-analysis of Observational Studies in Epidemiology Group, we systematically reviewed the literature on neonatal jaundice (unconjugated hyperbilirubinemia) and Autism Spectrum Disorder (ASD) in term and preterm infants. Thirteen studies were included in a meta-analysis. Most used retrospective matched case–control designs. There was significant heterogeneity (Q = 31, p = 0.002) and no evidence of publication bias (p = 0.12). Overall, jaundice, assessed by total serum bilirubin (TSB), was associated with ASD (OR, 1.43, 95% CI 1.22–1.67, random effect model). This association was not found in preterms (OR 0.7, 95% CI 0.38–1.02) but deserves further investigation since other measures of bilirubin such as unbound unconjugated bilirubin may be better predictors of neurotoxicity than TSB in preterms.

Keywords

Unconjugated hyperbilirubinemiaFree bilirubinPremature infantsMeta-analysis

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Division of Neonatology, Department of PediatricsThe University of Rochester School of Medicine and DentistryRochesterUSA
  2. 2.Division of Developmental Pediatrics, Department of PediatricsThe University of Rochester School of Medicine and DentistryRochesterUSA
  3. 3.Department of BiostatisticsThe University of Rochester School of Medicine and DentistryRochesterUSA